{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:49:56Z","timestamp":1792414196938,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["PG\u201022\u20100389\u2010H\u201001"],"award-info":[{"award-number":["PG\u201022\u20100389\u2010H\u201001"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      C\u2010tactile (CT) afferents have been proposed to play a key role in signalling the pleasant aspects of gentle touch, and individuals with hereditary disorders affecting CT function exhibit abnormal affective touch perception. We previously demonstrated that applying a thin elastic film to the skin alters the perceived pleasantness of brush stroking. Here, we investigated how a thin elastic film modulates responses in unmyelinated CT and myelinated low\u2010threshold mechanoreceptors. Using microneurography in human subjects, we found that the film markedly suppressed firing in CT afferents during gentle brushing. Likewise, myelinated low\u2010threshold mechanoreceptors generally showed a robust reduction in brushing responses following film application. In contrast, psychophysical measures revealed only a modest reduction in perceived touch pleasantness. Despite pronounced suppression of peripheral afferent activity, the perceptual effect remained limited. These findings suggest that the relationship between CT activity and pleasant touch perception may be more limited than often assumed, highlighting an important contribution of central processing.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70748-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>C\u2011tactile (CT) afferents are proposed to signal the pleasant aspects of gentle touch.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We examined how a thin elastic plastic film applied to the skin affects responses in CT afferents and myelinated low\u2011threshold mechanoreceptors (A\u2011LTMRs).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The film markedly suppressed firing during gentle brushing in both CTs and A\u2011LTMRs.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Despite this pronounced suppression, perceived touch pleasantness was only modestly reduced.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings suggest that the link between CT activity and pleasant touch perception may be more limited than often assumed, highlighting a substantial contribution of central processing.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jp290237","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:45:51Z","timestamp":1786621551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Marked C\u2010tactile afferent suppression by a plastic film does not proportionately diminish pleasantness of gentle brushing"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-1015","authenticated-orcid":false,"given":"Johan","family":"Nikesj\u00f6","sequence":"first","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-8232","authenticated-orcid":false,"given":"Saad S.","family":"Nagi","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Jarocka","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-4723","authenticated-orcid":false,"given":"Kevin K. W.","family":"Ng","sequence":"additional","affiliation":[{"name":"C\u00daRAM Research Ireland Centre for Medical Devices University of Galway  Galway Ireland"},{"name":"Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9230-2328","authenticated-orcid":false,"given":"Maja","family":"F\u00e4ltskytt","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-7089","authenticated-orcid":false,"given":"Andrew","family":"Marshall","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-6533","authenticated-orcid":false,"given":"Sarah","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-3822","authenticated-orcid":false,"given":"Gregory J.","family":"Gerling","sequence":"additional","affiliation":[{"name":"School of Engineering and Applied Science University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Olausson","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences (BKV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2847-13.2014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh3273"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","unstructured":"Bhuiyan S. 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