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However, this cortical region has many interconnections throughout the brain, overlapping with other systems. One such example is the vestibular system. Starting at the vestibular organs within the inner ear, the vestibular system plays a major role in nauseogenic responses, and many vestibular disorders do not have well\u2010documented treatment plans. Given the overlapping circuitry between the dlPFC and vestibular processing networks, it has been hypothesised that the two would have interactions with one another when stimulated. Indeed, recent work has shown transcranial alternating current stimulation of the dlPFC to have an inhibitory action on sinusoidal galvanic vestibular stimulation\u2010induced nausea and perceptions of motion. Furthermore, stimulating the dlPFC through transcranial direct current stimulation has reduced dizziness in a cohort of phobic postural vertigo patients. This review aims to introduce the vestibular system and vestibular\u2010based nausea, including the cortical processing network, before discussing the dlPFC as a potential site for therapeutic targeting in various vestibular\u2010related disease states. This targeting focusses on transcranial stimulation, first in vestibular disorders, then in generalised motion sickness, concluding with speculation upon its possible (though perhaps less probable) \u2018blue\u2010sky\u2019 use in chemotherapy\u2010induced nausea and vomiting.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70391-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  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