{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:57:56Z","timestamp":1781528276789,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102017\u201004243"],"award-info":[{"award-number":["RGPIN\u20102017\u201004243"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020951","name":"Fonds de recherche du Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"\n Abstract<\/jats:title>\n \n The mechanisms underlying impaired temperature regulation in older age, and the ability of older adults to physiologically adapt to heat exposure remain understudied. This study determined the effects of older age on the neural control of body temperature during heat stress and its plasticity in response to passive heat acclimation. The neural control of body temperature during heat stress was quantified with measurements of skin sympathetic nerve activity (SSNA), local sweat rate (LSR) and cutaneous vascular conductance (CVC) performed on older (\n n<\/jats:italic>\n \u00a0=\u00a015, 60\u201378\u00a0years) and younger (\n n<\/jats:italic>\n \u00a0=\u00a016, 21\u201340\u00a0years) adults before and after seven consecutive days of hot water immersion. Pre\u2010acclimation, the onset threshold of SSNA (mean difference [95% CI]: \u22120.12\u00b0C [\u22120.38, 0.15],\n P\u00a0=\u00a0<\/jats:italic>\n 0.518), LSR (\u22120.14\u00b0C [\u22120.37, 0.08],\n P\u00a0=\u00a0<\/jats:italic>\n 0.265) and CVC (\u22120.09\u00b0C [\u22120.33, 0.14],\n P\u00a0=\u00a0<\/jats:italic>\n 0.600) did not differ between older and younger adults. Heat acclimation reduced resting core temperature and increased sweating in both groups. Post\u2010acclimation, the onset threshold of SSNA (\u22120.19\u00b0C [\u22120.36, \u22120.02],\n P\u00a0=\u00a0<\/jats:italic>\n 0.024), LSR (\u22120.15\u00b0C [\u22120.29, 0.00],\n P\u00a0=\u00a0<\/jats:italic>\n 0.036), and CVC (\u22120.23\u00b0C [\u22120.41, \u22120.06],\n P\u00a0=\u00a0<\/jats:italic>\n 0.009) was reduced in older adults and these reductions did not differ from those observed in younger adults (\n P\u00a0<\/jats:italic>\n \u2265\u00a00.703). These results show that older age does not alter the neural control of body temperature during heat stress, nor its plasticity to heat acclimation. The implications of these results are that passive heat acclimation may be a practical strategy to improve the physiological resilience of older adults to extreme heat events.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n It remains unclear how older age modulates the neural control of body temperature during heat stress and its plasticity to heat acclimation.<\/jats:p>\n <\/jats:list-item>\n \n This study determined the effect of older age on the neural control of body temperature during heat stress before and after 7\u00a0days of heat acclimation.<\/jats:p>\n <\/jats:list-item>\n \n The results show that older age does not alter the neural control of body temperature during heat stress, nor its improvement with heat acclimation.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp290417","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:39:42Z","timestamp":1778524782000},"page":"4968-4983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heat acclimation improves the neural control of body temperature during heat stress in older adults"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-1939","authenticated-orcid":false,"given":"Thomas A.","family":"Deshayes","sequence":"first","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadiatou","family":"Barry","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de pharmacologie et physiologie, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8984-3875","authenticated-orcid":false,"given":"Amine","family":"Dahhak","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e8wanou Gilles Arnaud","family":"Sodabi","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Oubouchou","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsen","family":"Hsouna","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Debray","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Desrosiers\u2010Gagnon","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia K.","family":"Chaseling","sequence":"additional","affiliation":[{"name":"SOLVE\u2010CHD NHMRC Synergy Grant, Sydney Nursing School, Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia"},{"name":"Heat and Health Research Centre, School of Health Sciences, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gendron","sequence":"additional","affiliation":[{"name":"D\u00e9partement des sciences de l'activit\u00e9 physique Universit\u00e9 du Qu\u00e9bec \u00e0 Trois\u2010Rivi\u00e8res Trois\u2010Rivi\u00e8res Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-9489","authenticated-orcid":false,"given":"Daniel","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Montr\u00e9al Qu\u00e9bec Canada"},{"name":"\u00c9cole de kin\u00e9siologie et des sciences de l'activit\u00e9 physique, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01830-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02419-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279266"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M24-3504"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.034"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00177.2019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108610"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00250.2009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282038"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01208-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00012.2025"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03186-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00283.2017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2020.1832950"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00338.2010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004840050107"},{"key":"e_1_2_6_19_1","unstructured":"IPCC. (2014).Climate change 2014: Synthesis report. contribution of working groups I II and III to the fifth assessment report of the intergovernmental panel on climate change[Core Writing Team R. K.Pachauri &L. A.Meyer (Eds.) ] (p.151).IPCC."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03954-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(17)30178-X"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.3.1082"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2020.12.007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(22)00117-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2023"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105909"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP088783"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.3.531"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP088385"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00321.2020"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00701.2023"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01822-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.1.232"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00290.2013"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7537"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00730.2016"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2014.tb00547.x"},{"key":"e_1_2_6_38_1","first-page":"267","volume-title":"World report on ageing and health","author":"World Health Organization","year":"2015"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.18356\/9789211074017c010"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP290417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP290417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP290417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:41:28Z","timestamp":1781527288000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP290417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1113\/JP290417"],"URL":"https:\/\/doi.org\/10.1113\/jp290417","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}