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Progress in this field has been substantially hampered by the scarcity of valid animal models and the difficulty in establishing them. Here we presented flashing lights at varying frequencies to head\u2010fixed mice while recording local field potentials (LFPs) in the primary visual cortex (V1). We identified approximately 5 Hz as the resonant frequency for eliciting photosensitive responses. By modulating the luminance within the behavioural chamber we found that the response amplitude diminished with reduced stimulus contrast. Dual\u2010region LFP recordings revealed that the photosensitive response propagated to the medial prefrontal cortex (mPFC), with the response in V1 being both stronger and earlier than those in the mPFC. Acute treatment with pentylenetetrazole (PTZ) enhanced the photosensitive response in V1, whereas chronic PTZ treatment did not. Furthermore we demonstrated that several anti\u2010epileptic drugs effectively attenuated the photosensitive response in both V1 and mPFC. Collectively our findings establish a murine photosensitivity model as a promising platform for the investigation of the mechanisms underlying photosensitive epilepsy and for the initial screening of potential antiepileptic therapeutics.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n The resonant frequency of the photosensitive response in mice is approximately 5 Hz.<\/jats:p>\n <\/jats:list-item>\n \n Photosensitive response decreases as the stimulus contrast reduces, and its response to red light is weaker than that to white light.<\/jats:p>\n <\/jats:list-item>\n \n The photosensitive response can propagate to the medial prefrontal cortex (mPFC) region but does not induce clinical epileptic seizures.<\/jats:p>\n <\/jats:list-item>\n \n Some anti\u2010epileptic drugs can alleviate the photosensitive response.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n 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