{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:44:52Z","timestamp":1792334692001,"version":"4.4.0"},"reference-count":140,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["310891\/Z\/24\/Z"],"award-info":[{"award-number":["310891\/Z\/24\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000674","name":"Physiological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011856","name":"Mauritius Research Council","doi-asserted-by":"publisher","award":["MR\/X018067\/1"],"award-info":[{"award-number":["MR\/X018067\/1"]}],"id":[{"id":"10.13039\/501100011856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite significant advances in early detection and therapeutic opportunities, cancer remains a critical global health challenge. The greatest barrier to reducing cancer\u2010associated mortality is the persistent problem of therapeutic resistance and metastasis. Standard treatment approaches, including surgery combined with chemotherapy and radiation, are effective for many patients with localised disease. However, a substantial proportion of patients will experience recurrence and therapy resistance, leading to treatment failure and poor outcomes. This adverse prognosis for patients highlights the critical need to identify new therapeutic targets capable of improving long\u2010term survival. The ion transportome comprises ion channels, solute transporters and pumps that regulate controlled movement of sodium (Na\n                    <jats:sup>+<\/jats:sup>\n                    ), potassium (K\n                    <jats:sup>+<\/jats:sup>\n                    ), calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ), chloride (Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and hydrogen (H\n                    <jats:sup>+<\/jats:sup>\n                    ) across cell membranes. Ion transport is central to many cellular processes, including cell growth, volume regulation, proliferation and migration. In many solid tumours, the finely tuned ionic balance becomes dysregulated, with aberrant expression or activity of membrane transport proteins being closely linked to many of the hallmarks of cancer. Ion channel modulation using pharmacological agents designed to treat channelopathies has demonstrated promise in suppressing cancer progression in preclinical models. Thus, targeting ion\u2010driven vulnerabilities within solid tumours may complement existing therapies to overcome resistance and improve patient outcomes. The dynamic nature of ion transport mechanisms means that addressing critical research questions regarding their suitability as pharmacological targets is challenging, highlighting the need to develop innovative approaches to study these processes in oncology.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70879-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp290738","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:21:42Z","timestamp":1792333302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Harnessing the ion transportome to treat cancer"],"prefix":"10.1113","author":[{"given":"Alina L.","family":"Capatina","sequence":"first","affiliation":[{"name":"Jack Birch Cancer Research Unit, York Biomedical Research Institute, Department of Biology University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie R.","family":"Malcolm","sequence":"additional","affiliation":[{"name":"Jack Birch Cancer Research Unit, York Biomedical Research Institute, Department of Biology University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Centre for Cell and Molecular Dynamics 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