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This study examined whether supine cycling exercise, with\/without artificial gravity (AG), preserves resting metabolic rate (RMR) during 60\u00a0days of bed rest, and whether RMR responses align with integrated multivariate physiological adaptations. Twenty\u2010four healthy men were randomly assigned to control (C), cycling (EX) or cycling plus AG (EX\u2010AG). RMR, substrate oxidation, body composition (dual\u2010energy X\u2010ray absorptiometry\/magnetic resonance imaging), muscle function and maximal cycling power were assessed before and after bed rest. Linear mixed models evaluated group\u2010by\u2010time effects. Principal component analysis (PCA) and sparse partial least squares (sPLS) regression examined multivariate correlates of \u0394RMR. RMR responses differed between groups (interaction\n P<\/jats:italic>\n \u00a0=\u00a00.029), with EX\u2010AG preventing the decline observed in C (EX\u2010AG\n vs<\/jats:italic>\n . C \u0394\u0394\u00a0=\u00a0+133\u00a0kcal\u00a0day\n \u22121<\/jats:sup>\n ,\n P<\/jats:italic>\n \u00a0=\u00a00.017). Fat oxidation remained stable in EX\u2010AG but declined in C and EX. Both interventions attenuated lower\u2010body fat\u2010free mass loss, with greater preservation under EX\u2010AG, yet neuromuscular function deteriorated similarly across groups. Maximal cycling power exhibited a significant interaction (\n P<\/jats:italic>\n \u00a0<\u00a00.001), declining in C, being maintained in EX and increasing in EX\u2010AG. PCA revealed two dominant axes: PC1 (25.9% variance) reflected preservation of fat\u2010free tissues, whereas PC2 (17.9%) captured gains in abdominal adiposity. EX\u2010AG participants clustered toward higher PC1 values, indicating tissue preservation. The sPLS model (\n r<\/jats:italic>\n \u00a0=\u00a00.72) identified respiratory ratio changes (\u0394RQ) as the dominant contributor. Exercise combined with AG preserves resting metabolism but does not prevent neuromuscular decline. Multivariate analyses indicate that substrate utilization and preservation of metabolically active lean compartments underpin RMR maintenance during unloading.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n Cycling exercise combined with artificial gravity appeared to preserve resting metabolic rate during long\u2010term (60\u00a0days) head\u2010down tilt bed rest.<\/jats:p>\n <\/jats:list-item>\n \n Cycling with\/without artificial gravity failed to prevent declines in maximal voluntary contraction or jump performance induced by 60\u00a0days of bed rest, although it preserved cycling power.<\/jats:p>\n <\/jats:list-item>\n \n We show that metabolic and neuromuscular adaptations to bed rest may be partially dissociated, with artificial gravity primarily sustaining basal metabolic regulation while failing to maintain skeletal muscle contractile function.<\/jats:p>\n <\/jats:list-item>\n \n The dissociation between metabolic and mechanical adaptations reported here provides valuable insight into the regulation of energy expenditure and muscle function in other contexts of severe inactivity, such as immobilization or ageing.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp290788","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T01:03:32Z","timestamp":1779671012000},"page":"4771-4794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study"],"prefix":"10.1113","volume":"604","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-5309","authenticated-orcid":false,"given":"Saul","family":"Martin\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Division of 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