{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:40:05Z","timestamp":1784248805255,"version":"3.55.0"},"reference-count":115,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201021\u20101\u20100187"],"award-info":[{"award-number":["W81XWH\u201021\u20101\u20100187"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"\n Abstract<\/jats:title>\n \n Rehabilitative activity can improve injury repair, but it risks additional damage and reduces the functional recovery of regenerating muscle. This study tested the hypothesis that moderate electrically evoked contractions would slow restoration of neuromuscular function after cardiotoxin\u2010induced injury; however exogenous mitochondrial transplantation (MT) would enhance recovery of contractile function after injury. Cardiotoxin was injected into the tibialis anterior of C57BL\/6 mice (10\u201312\u00a0weeks of age) to induce muscle necrosis. Exogenous mitochondria or phosphate\u2010buffered saline (PBS) were injected into the mouse tail vein after cardiotoxin injury. Injured muscles were either rested or given 40 Hz submaximal electrically evoked contractions to cardiotoxin\u2010injured muscles during the recovery period. Relative to intra\u2010animal non\u2010damaged control muscles restoration of peak tetanic torque after both rested and evoked contractions during recovery and twitch torque was greater, and the difference between control and injured muscle twitch one\u2010half relaxation time was lower in injured muscles that were rested for 10\u00a0days after injury and received MT compared to PBS\u2010treated muscles. Neuromuscular junction efficiency in cardiotoxin\u2010injured muscles was \u223c70% of control undamaged muscles, but MT improved the recovery of neuromuscular junction efficiency to produce torque by 14\u00a0days after cardiotoxin injury in muscles that received additional damage induced by evoked contractions during the recovery period. These data suggest that MT enhances the recovery of neuromuscular function when the muscle is rested after injury, but it provides limited improvement in muscle function when the muscle is challenged with electrically evoked contractions in the recovery period after injury.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n Mitochondrial transplantation by systemically infusing healthy donor mitochondria into injured mice improved the recovery of maximal torque production of injured muscles when evoked contractions were provided to the regenerating muscle during the recovery period after injury.<\/jats:p>\n <\/jats:list-item>\n \n Mitochondrial transplantation improved the restoration of neuromuscular junction efficiency after muscle injury.<\/jats:p>\n <\/jats:list-item>\n \n The recovery of maximal torque capabilities function following cardiotoxin\u2010induced tibialis anterior muscle injury was attenuated by electrically evoked muscle contractions conducted every other day during the recovery period in young adult mice.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp290801","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:48:07Z","timestamp":1779432487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Restoration of neuromuscular function by mitochondrial transplantation in injured mouse skeletal muscle"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-4707","authenticated-orcid":false,"given":"Stephen E.","family":"Alway","sequence":"first","affiliation":[{"name":"Laboratory of Muscle Biology and Sarcopenia, Division of Regenerative and Rehabilitation Sciences, and the Department of Physical Therapy, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Center for Muscle, Metabolism and Neuropathology, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Ferrandi","sequence":"additional","affiliation":[{"name":"Center for Muscle, Metabolism and Neuropathology, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Integrated Biomedical Sciences Graduate Program, College of Graduate Health Sciences University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Laboratory of Muscle and Nerve, Department of Diagnostic and Health Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector G.","family":"Paez","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Biology and Sarcopenia, Division of Regenerative and Rehabilitation Sciences, and the Department of Physical Therapy, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Center for Muscle, Metabolism and Neuropathology, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Integrated Biomedical Sciences Graduate Program, College of Graduate Health Sciences University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Comparative Biosciences, College of Veterinary Medicine University of Wisconsin Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2529-4880","authenticated-orcid":false,"given":"Christopher R.","family":"Pitzer","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Biology and Sarcopenia, Division of Regenerative and Rehabilitation Sciences, and the Department of Physical Therapy, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Center for Muscle, Metabolism and Neuropathology, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Integrated Biomedical Sciences Graduate Program, College of Graduate Health Sciences University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Centre for Exercise Medicine Research Fralin Biomedical Research Institute at VTC Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junaith S.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Center for Muscle, Metabolism and Neuropathology, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Integrated Biomedical Sciences Graduate Program, College of Graduate Health Sciences University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Laboratory of Muscle and Nerve, Department of Diagnostic and Health Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Deschenes","sequence":"additional","affiliation":[{"name":"Department of Kinesiology College of William & Mary Williamsburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Carson","sequence":"additional","affiliation":[{"name":"Center for Muscle, Metabolism and Neuropathology, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Integrative Muscle Biology Laboratory, Division of Regenerative and Rehabilitation Sciences, College of Health Professions University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Integrative Muscle Biology Laboratory, Huffines Institute for Sports Medicine & Human Performance, Department of Kinesiology & Sports Management Department Texas A&M University College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"issue":"7","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014501","article-title":"Bioenergetics consequences of mitochondrial transplantation in cardiomyocytes","volume":"9","author":"Ali Pour P.","year":"2020","journal-title":"Journal of the American Heart Association"},{"issue":"2","key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0047-6374(94)90059-0","article-title":"Contractile properties of aged avian muscle after stretch\u2010overload","volume":"73","author":"Alway S. E.","year":"1994","journal-title":"Mechanisms of Ageing and Development"},{"issue":"1","key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"B26","DOI":"10.1093\/gerona\/50A.1.B26","article-title":"Slowing of contractile properties in quail skeletal muscle with aging","volume":"50","author":"Alway S. E.","year":"1995","journal-title":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences"},{"issue":"5","key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0531-5565(02)00003-7","article-title":"Attenuation of Ca2+\u2010activated ATPase and shortening velocity in hypertrophied fast twitch skeletal muscle from aged Japanese quail","volume":"37","author":"Alway S. E.","year":"2002","journal-title":"Experimental Gerontology"},{"issue":"6","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1152\/jappl.1989.66.6.2725","article-title":"Contractile adaptations in the human triceps surae after isometric exercise","volume":"66","author":"Alway S. E.","year":"1989","journal-title":"Journal of Applied Physiology"},{"issue":"2","key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"R540","DOI":"10.1152\/ajpregu.00550.2002","article-title":"Id2 expression during apoptosis and satellite cell activation in unloaded and loaded quail skeletal muscles","volume":"284","author":"Alway S. E.","year":"2003","journal-title":"American Journal of Physiology\u2010Regulatory, Integrative and Comparative Physiology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/B978-0-12-378638-8.00004-X","volume-title":"Handbooks of aging, handbook of the biology of aging","author":"Alway S. E.","year":"2011"},{"issue":"1","key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"C83","DOI":"10.1152\/ajpcell.00744.2025","article-title":"Mitochondria transplantation mitigates attenuation of muscle fiber regeneration by evoked contractions","volume":"330","author":"Alway S. E.","year":"2026","journal-title":"American Journal of Physiology\u2010Cell Physiology"},{"issue":"2","key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/muscles2020011","article-title":"The role of mitochondria in mediation of skeletal muscle repair","volume":"2","author":"Alway S. E.","year":"2023","journal-title":"Muscles"},{"issue":"1","key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcsm.13153","article-title":"Mitochondria transplant therapy improves regeneration and restoration of injured skeletal muscle","volume":"14","author":"Alway S. E.","year":"2023","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"7","key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1519\/JSC.0000000000004793","article-title":"Mitochondria transplantation: Rescuing innate muscle bioenergetic impairment in a model of aging and exercise intolerance","volume":"38","author":"Arroum T.","year":"2024","journal-title":"Journal of Strength & Conditioning Research"},{"issue":"1","key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0014-5793(86)81428-4","article-title":"Ca2+ activation of troponin C\u2010extracted vertebrate striated fast\u2010twitch muscle fibers","volume":"203","author":"Babu A.","year":"1986","journal-title":"Federation of European Biochemical Societies Letters"},{"issue":"1","key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/JES.0b013e3181c5cd7c","article-title":"Skeletal muscle injury versus adaptation with aging: Novel insights on perplexing paradigms","volume":"38","author":"Baker B. A.","year":"2010","journal-title":"Exercise and Sport Sciences Reviews"},{"issue":"9","key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.stem.2022.07.010","article-title":"The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells","volume":"29","author":"Baker N.","year":"2022","journal-title":"Cell Stem Cell"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3938672"},{"issue":"4","key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"C862","DOI":"10.1152\/ajpcell.00212.2023","article-title":"Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis","volume":"325","author":"Bhattacharya D.","year":"2023","journal-title":"American Journal of Physiology\u2010Cell Physiology"},{"issue":"8","key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nm.3918","article-title":"The central role of muscle stem cells in regenerative failure with aging","volume":"21","author":"Blau H. M.","year":"2015","journal-title":"Nature Medicine"},{"issue":"6","key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1152\/japplphysiol.00451.2017","article-title":"Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice","volume":"124","author":"Brooks M. J.","year":"2018","journal-title":"Journal of Applied Physiology"},{"issue":"8","key":"e_1_2_5_20_1","first-page":"1597","article-title":"Regenerative inflammation: When immune cells help to re\u2010build tissues","volume":"291","author":"Caballero\u2010S\u00e1nchez N.","year":"2022","journal-title":"The Federation of European Biochemical Societies Journal"},{"issue":"2","key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"C578","DOI":"10.1152\/ajpcell.1996.270.2.C578","article-title":"Stretch overload\u2010induced satellite cell activation in slow tonic muscle from adult and aged Japanese quail","volume":"270","author":"Carson J. A.","year":"1996","journal-title":"American Journal of Physiology\u2010Cell Physiology"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122941","article-title":"Mitochondrial fragmentation in early differentiation of human MB135 myoblasts: Role of mitochondrial ROS production in the absence of depolarization","volume":"354","author":"Chernyavskij D. A.","year":"2024","journal-title":"Life Sciences"},{"issue":"5","key":"e_1_2_5_23_1","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.70064","article-title":"The effect of cachexia on the feeding regulation of skeletal muscle protein synthesis in tumour\u2010bearing mice","volume":"16","author":"Counts B. R.","year":"2025","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.589770","article-title":"Targeting NR4A nuclear receptors to control stromal cell inflammation, metabolism, angiogenesis, and tumorigenesis","volume":"9","author":"Crean D.","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"36","key":"e_1_2_5_25_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302360120","article-title":"Impaired age\u2010associated mitochondrial translation is mitigated by exercise and PGC\u20101alpha","volume":"120","author":"De Smalen L. M.","year":"2023","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"e_1_2_5_26_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0838.2009.01018.x","article-title":"The role of systemic inflammation in age\u2010related muscle weakness and wasting","volume":"20","author":"Degens H.","year":"2010","journal-title":"Scandinavian Journal of Medicine & Science in Sports"},{"issue":"3","key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1874609811104030209","article-title":"Motor unit and neuromuscular junction remodeling with aging","volume":"4","author":"Deschenes M. R.","year":"2011","journal-title":"Current Aging Sciencee"},{"issue":"7","key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3390\/cells11071150","article-title":"Adaptive remodeling of the neuromuscular junction with aging","volume":"11","author":"Deschenes M. R.","year":"2022","journal-title":"Cells"},{"issue":"4","key":"e_1_2_5_29_1","doi-asserted-by":"crossref","DOI":"10.1002\/syn.70022","article-title":"Efficacy of mitochondrial transfer in healing toxin\u2010induced damage to neuromuscular junction, an empirical study","volume":"79","author":"Deschenes M. R.","year":"2025","journal-title":"Synapse"},{"key":"e_1_2_5_30_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2020.07.001","article-title":"Effects of exercise training on neuromuscular junctions and their active zones in young and aged muscles","volume":"95","author":"Deschenes M. R.","year":"2020","journal-title":"Neurobiology of Aging"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123563","article-title":"Therapeutic mitochondrial transfer via mesenchymal stem cell\u2010derived microvesicles for macrophage modulation in myocardial infarction complicated by diabetes","volume":"325","author":"Dong Z.","year":"2026","journal-title":"Biomaterials"},{"issue":"3","key":"e_1_2_5_32_1","first-page":"387","article-title":"Bone development and age\u2010related bone loss in male C57BL\/6J mice","volume":"33","author":"Ferguson V. L.","year":"2003","journal-title":"Bone (New York)"},{"issue":"1","key":"e_1_2_5_33_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1152\/physrev.1994.74.1.49","article-title":"Cellular mechanisms of muscle fatigue","volume":"74","author":"Fitts R. H.","year":"1994","journal-title":"Physiological Reviews"},{"issue":"5","key":"e_1_2_5_34_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3390\/cells9051297","article-title":"Mechanisms regulating muscle regeneration: Insights into the interrelated and time\u2010dependent phases of tissue healing","volume":"9","author":"Forcina L.","year":"2020","journal-title":"Cells"},{"issue":"9","key":"e_1_2_5_35_1","article-title":"Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age","volume":"10","author":"Fraczek P. M.","year":"2025","journal-title":"Journal of Clinical Investigation Insight"},{"issue":"4","key":"e_1_2_5_36_1","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqaf031","article-title":"Skeletal muscle stem cell mitochondria are transferred to muscle fibers in response to a hypertrophic stimulus","volume":"6","author":"Goh J.","year":"2025","journal-title":"Function"},{"key":"e_1_2_5_37_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.653322","article-title":"Mitochondria donation by mesenchymal stem cells: Current understanding and mitochondria transplantation strategies","volume":"9","author":"Gomzikova M. O.","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"3","key":"e_1_2_5_38_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/bioa.29668","article-title":"Therapies for sarcopenia and regeneration of old skeletal muscles: More a case of old tissue architecture than old stem cells","volume":"4","author":"Grounds M. D.","year":"2014","journal-title":"Bioarchitecture"},{"issue":"12","key":"e_1_2_5_39_1","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1113\/JP270818","article-title":"Principles and standards for reporting animal experiments in The Journal of Physiology and Experimental Physiology","volume":"593","author":"Grundy D.","year":"2015","journal-title":"The Journal of Physiology"},{"issue":"2","key":"e_1_2_5_40_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147215","article-title":"Targeted energy metabolomics analysis\u2010based mitochondrial restoration: Nutritional intervention of dairy\u2010derived MFG\u2010E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration","volume":"323","author":"Guan K.","year":"2025","journal-title":"International Journal of Biological Macromolecules"},{"issue":"1","key":"e_1_2_5_41_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70355","article-title":"Age\u2010associated dysregulation of postsynaptic mitochondria perturbs reinnervation kinetics","volume":"25","author":"Guzman S. D.","year":"2026","journal-title":"Aging Cell"},{"issue":"2","key":"e_1_2_5_42_1","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1152\/ajpendo.00096.2023","article-title":"Recovery from FOLFOX chemotherapy\u2010induced systemic and skeletal muscle metabolic dysfunction in mice","volume":"325","author":"Halle J. L.","year":"2023","journal-title":"American Journal of Physiology\u2010Endocrinology and Metabolism"},{"issue":"2","key":"e_1_2_5_43_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/jappl.2001.91.2.534","article-title":"Myogenic satellite cells: Physiology to molecular biology","volume":"91","author":"Hawke T. J.","year":"2001","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_5_44_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102251","article-title":"Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic stress as potential therapeutic target","volume":"51","author":"Heher P.","year":"2022","journal-title":"Redox Biology"},{"issue":"9","key":"e_1_2_5_45_1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.stem.2022.07.009","article-title":"Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy","volume":"29","author":"Hong X.","year":"2022","journal-title":"Cell Stem Cell"},{"key":"e_1_2_5_46_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","article-title":"Maintenance of skeletal muscle mitochondria in health, exercise, and aging","volume":"81","author":"Hood D. A.","year":"2019","journal-title":"Annual Review of Physiology"},{"key":"e_1_2_5_47_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/bs.ctdb.2017.08.008","article-title":"Muscle stem cells and aging","volume":"126","author":"Hwang A. B.","year":"2018","journal-title":"Current Topics in Developmental Biology"},{"key":"e_1_2_5_48_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2023.11.007","article-title":"Role of F\u2010actin\u2010mediated endocytosis and exercise in mitochondrial transplantation in an experimental Parkinson's disease mouse model","volume":"74","author":"Jain R.","year":"2024","journal-title":"Mitochondrion"},{"key":"e_1_2_5_49_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101933","article-title":"Differentiation activates mitochondrial OPA1 processing in myoblast cell lines","volume":"78","author":"Kaur H.","year":"2024","journal-title":"Mitochondrion"},{"issue":"4","key":"e_1_2_5_50_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jtcvs.2016.10.077","article-title":"Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia\/reperfusion","volume":"153","author":"Kaza A. K.","year":"2017","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"13","key":"e_1_2_5_51_1","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.3390\/cells12131751","article-title":"Metabolic \u201csense relay\u201d in stem cells: A short but impactful life of PAS kinase balancing stem cell fates","volume":"12","author":"Kikani C. K.","year":"2023","journal-title":"Cells"},{"issue":"6","key":"e_1_2_5_52_1","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1002\/jcsm.13348","article-title":"TAZ stimulates exercise\u2010induced muscle satellite cell activation via Pard3\u2010p38 MAPK\u2010TAZ signalling axis","volume":"14","author":"Kim K. M.","year":"2023","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"key":"e_1_2_5_53_1","doi-asserted-by":"crossref","DOI":"10.1177\/09636897251347391","article-title":"Comparative analysis of mitochondrial and mesenchymal stem cell transplantation for angiogenesis and muscle regeneration","volume":"34","author":"Kim M. J.","year":"2025","journal-title":"Cell Transplantation"},{"key":"e_1_2_5_54_1","first-page":"213","article-title":"Therapeutic exercises for rehabilitation of muscle injury","volume":"41","author":"King M. R.","year":"2025","journal-title":"Veterinary Clinics of North America: Equine Practice"},{"issue":"1","key":"e_1_2_5_55_1","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1038\/s41467-025-61239-6","article-title":"Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation","volume":"16","author":"Kubat G. B.","year":"2025","journal-title":"Nature Communications"},{"key":"e_1_2_5_56_1","unstructured":"Leary S. L. Underwood W. Anthony R. Cartner S. Grandin T. Greenacre C. Gwaltney\u2010Brant S. McCrackin M. A. Meyer R. Miller D. Shearer J. Turner T. &Yanong R.(2020).AVMA guidelines for the euthanasia of animals: 2020 Edition. InAmerican veterinary medical association(pp.1\u2013121)."},{"issue":"24","key":"e_1_2_5_57_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415734","article-title":"Preferred migration of mitochondria toward cells and tissues with mitochondrial damage","volume":"23","author":"Lee S. E.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"17","key":"e_1_2_5_58_1","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.067595","article-title":"An absolute requirement for Pax7\u2010positive satellite cells in acute injury\u2010induced skeletal muscle regeneration","volume":"138","author":"Lepper C.","year":"2011","journal-title":"Development"},{"key":"e_1_2_5_59_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.663384","article-title":"HDAC4 knockdown alleviates denervation\u2010induced muscle atrophy by inhibiting myogenin\u2010dependent atrogene activation","volume":"15","author":"Ma W.","year":"2021","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"20","key":"e_1_2_5_60_1","first-page":"3261","article-title":"Effects of series elastic compliance on muscle force summation and the rate of force rise","volume":"219","author":"Mayfield D. L.","year":"2016","journal-title":"Journal of Experimental Biology"},{"issue":"22","key":"e_1_2_5_61_1","first-page":"3587","article-title":"Additional in\u2010series compliance reduces muscle force summation and alters the time course of force relaxation during fixed\u2010end contractions","volume":"219","author":"Mayfield D. L.","year":"2016","journal-title":"Journal of Experimental Biology"},{"key":"e_1_2_5_62_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1268814","article-title":"Mitochondrial transplantation: The advance to therapeutic application and molecular modulation","volume":"10","author":"McCully J. D.","year":"2023","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"1","key":"e_1_2_5_63_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40169-016-0095-4","article-title":"Mitochondrial transplantation for therapeutic use","volume":"5","author":"McCully J. D.","year":"2016","journal-title":"Clinical and Translational Medicine"},{"issue":"15","key":"e_1_2_5_64_1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1101\/gad.247205.114","article-title":"Myomaker is essential for muscle regeneration","volume":"28","author":"Millay D. P.","year":"2014","journal-title":"Genes & Development"},{"issue":"15","key":"e_1_2_5_65_1","first-page":"1641","article-title":"Skeletal muscle gene expression profile in response to caloric restriction and aging: A role for SirT1","volume":"12","author":"Myers M. J.","year":"2021","journal-title":"Genes (Basel)"},{"issue":"4","key":"e_1_2_5_66_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jcsm.12437","article-title":"The role of SIRT1 in skeletal muscle function and repair of older mice","volume":"10","author":"Myers M. J.","year":"2019","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"key":"e_1_2_5_67_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US) Institute for Laboratory Animal Research","year":"2011"},{"issue":"10","key":"e_1_2_5_68_1","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1113\/JP286666","article-title":"Update on requirements for ethics and welfare reporting in The Journal of Physiology","volume":"602","author":"O'Halloran K. D.","year":"2024","journal-title":"The Journal of Physiology"},{"issue":"2","key":"e_1_2_5_69_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4055\/cios.2018.10.2.119","article-title":"Treatment strategy for irreparable rotator cuff tears","volume":"10","author":"Oh J. H.","year":"2018","journal-title":"Clinics in Orthopedic Surgery"},{"issue":"2","key":"e_1_2_5_70_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ar.1092080203","article-title":"Myosatellite cells, growth, and regeneration in murine dystrophic muscle: A quantitative study","volume":"208","author":"Ontell M.","year":"1984","journal-title":"The Anatomical Record"},{"issue":"3","key":"e_1_2_5_71_1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jvs.2019.03.079","article-title":"Mitochondrial transplantation ameliorates acute limb ischemia","volume":"71","author":"Orfany A.","year":"2019","journal-title":"Journal of Vascular Surgery"},{"issue":"8","key":"e_1_2_5_72_1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202202029R","article-title":"Loss of NOR\u20101 represses muscle metabolism through mTORC1\u2010mediated signaling and mitochondrial gene expression in C2C12 myotubes","volume":"37","author":"Paez H. G.","year":"2023","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"issue":"8","key":"e_1_2_5_73_1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500375R","article-title":"NOR\u20101 overexpression elevates myoglobin expression via PERM1 and enhances mitochondrial function and endurance in skeletal muscles of aged mice","volume":"39","author":"Paez H. G.","year":"2025","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"issue":"1","key":"e_1_2_5_74_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s11357-025-01726-2","article-title":"Impact of sarcopenia and obesity on skeletal muscle size, gene expression, and mitochondrial function","volume":"48","author":"Paez H. G.","year":"2025","journal-title":"Geroscience"},{"issue":"7","key":"e_1_2_5_75_1","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1113\/JP280389","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"598","author":"Percie Du Sert N.","year":"2020","journal-title":"The Journal of Physiology"},{"issue":"15","key":"e_1_2_5_76_1","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1113\/JP281673","article-title":"Macrophage plasticity in Duchenne muscular dystrophy: A nexus of pathological remodelling with therapeutic implications","volume":"600","author":"Petrof B. J.","year":"2022","journal-title":"The Journal of Physiology"},{"issue":"1","key":"e_1_2_5_77_1","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.14814\/phy2.15898","article-title":"Extracellular vesicles from diabetic mouse plasma alter C2C12 myotube glucose uptake and gene expression","volume":"12","author":"Pitzer C. R.","year":"2024","journal-title":"Physiological Reports"},{"key":"e_1_2_5_78_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2022.107200","article-title":"Primary traumatic shoulder dislocation associated with rotator cuff tear in the elderly","volume":"95","author":"Prasetia R.","year":"2022","journal-title":"International Journal of Surgery Case Reports"},{"key":"e_1_2_5_79_1","article-title":"Rapid isolation and purification of mitochondria for transplantation by tissue dissociation and differential filtration","volume":"91","author":"Preble J. M.","year":"2014","journal-title":"Journal of Visualized Experiments: JoVE"},{"key":"e_1_2_5_80_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2026.01.015","article-title":"Fiber\u2010type\u2010specific architecture and pathophysiology of the neuromuscular junction","volume":"597","author":"Qaisar R.","year":"2026","journal-title":"Neuroscience"},{"issue":"1","key":"e_1_2_5_81_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.csm.2008.08.009","article-title":"Stem cells for the treatment of skeletal muscle injury","volume":"28","author":"Quintero A. J.","year":"2009","journal-title":"Clinics in Sports Medicine"},{"issue":"11","key":"e_1_2_5_82_1","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31155","article-title":"Augmented mitochondrial apoptotic signaling impairs C2C12 myoblast differentiation following cellular aging through sequential passaging","volume":"239","author":"Rahman F. A.","year":"2024","journal-title":"Journal of Cellular Physiology"},{"issue":"1","key":"e_1_2_5_83_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41467-020-20760-6","article-title":"Perspectives on skeletal muscle stem cells","volume":"12","author":"Relaix F.","year":"2021","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_5_84_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/JES.0b013e3181911fa4","article-title":"Sarcoplasmic reticulum\u2010mitochondrial symbiosis: Bidirectional signaling in skeletal muscle","volume":"37","author":"Rossi A. E.","year":"2009","journal-title":"Exercise and Sport Sciences Reviews"},{"issue":"2","key":"e_1_2_5_85_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.stem.2014.12.004","article-title":"The NAD+\u2010dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells","volume":"16","author":"Ryall J. G.","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"1","key":"e_1_2_5_86_1","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1038\/s41467-018-07253-3","article-title":"Age\u2010related declines in alpha\u2010klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration","volume":"9","author":"Sahu A.","year":"2018","journal-title":"Nature Communications"},{"issue":"17","key":"e_1_2_5_87_1","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1242\/dev.067587","article-title":"Pax7\u2010expressing satellite cells are indispensable for adult skeletal muscle regeneration","volume":"138","author":"Sambasivan R.","year":"2011","journal-title":"Development"},{"issue":"3","key":"e_1_2_5_88_1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3390\/ijms26031192","article-title":"Oxidative high mobility group box\u20101 accelerates mitochondrial transfer from mesenchymal stem cells to colorectal cancer cells providing cancer cell stemness","volume":"26","author":"Sasaki R.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_5_89_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/aja.1001470105","article-title":"Fine structure of satellite cells in growing skeletal muscle","volume":"147","author":"Schultz E.","year":"1976","journal-title":"American Journal of Anatomy"},{"issue":"3","key":"e_1_2_5_90_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/jez.1402060314","article-title":"Satellite cells are mitotically quiescent in mature mouse muscle: An EM and radioautographic study","volume":"206","author":"Schultz E.","year":"1978","journal-title":"Journal of Experimental Zoology"},{"issue":"3","key":"e_1_2_5_91_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/mus.880080307","article-title":"Response of satellite cells to focal skeletal muscle injury","volume":"8","author":"Schultz E.","year":"1985","journal-title":"Muscle & Nerve"},{"issue":"12","key":"e_1_2_5_92_1","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.cmet.2022.09.013","article-title":"Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The human pancreas analysis program","volume":"34","author":"Shapira S. N.","year":"2022","journal-title":"Cell Metabolism"},{"issue":"4","key":"e_1_2_5_93_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1101\/gad.293167.116","article-title":"The metabolic programming of stem cells","volume":"31","author":"Shyh\u2010Chang N. &.","year":"2017","journal-title":"Genes & Development"},{"issue":"13","key":"e_1_2_5_94_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.lfs.2009.01.014","article-title":"Apoptotic signaling induced by H2O2\u2010mediated oxidative stress in differentiated C2C12 myotubes","volume":"84","author":"Siu P. M.","year":"2009","journal-title":"Life Sciences"},{"issue":"10","key":"e_1_2_5_95_1","doi-asserted-by":"crossref","DOI":"10.1111\/eci.70073","article-title":"Mesenchymal stem cell\u2010mediated mitochondrial transfer regulates the fate of B lymphocytes","volume":"55","author":"Somova V.","year":"2025","journal-title":"European Journal of Clinical Investigation"},{"key":"e_1_2_5_96_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.153044","article-title":"Mitochondrial transplantation alleviates acute pancreatitis by suppressing macrophage necroptosis","volume":"794","author":"Sun C.","year":"2026","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"e_1_2_5_97_1","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/9802235","article-title":"Modelling skeletal muscle ageing and repair In vitro","volume":"2023","author":"Tarum J.","year":"2023","journal-title":"Journal of Tissue Engineering and Regenerative Medicine"},{"issue":"5","key":"e_1_2_5_98_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00004630-199209000-00007","article-title":"Modification of calcium flux of twitch skeletal muscle in mice subjected to 20% body surface area burn","volume":"13","author":"Tomera J. F.","year":"1992","journal-title":"Journal of Burn Care & Rehabilitation"},{"issue":"12","key":"e_1_2_5_99_1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401856RRR","article-title":"Mitochondria\u2010homing drug mitochonic acid 5 improves Barth syndrome myopathy in a Human\u2010induced pluripotent stem cell model and Barth syndrome drosophila model","volume":"39","author":"Tongu Y.","year":"2025","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"issue":"3","key":"e_1_2_5_100_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109164","article-title":"Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1","volume":"27","author":"Triolo M.","year":"2024","journal-title":"Iscience"},{"issue":"2","key":"e_1_2_5_101_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2024.149532","article-title":"Acute treadmill exercise induces mitochondrial unfolded protein response in skeletal muscle of male rats","volume":"1866","author":"Turkel I.","year":"2025","journal-title":"Biochimica et Biophysica Acta (BBA) \u2010 Bioenergetics"},{"issue":"4","key":"e_1_2_5_102_1","doi-asserted-by":"crossref","first-page":"C1214","DOI":"10.1152\/ajpcell.00187.2025","article-title":"Short\u2010term daily deflazacort decreases membrane permeability and increases maximum force in mdx mice","volume":"329","author":"Turner K. D.","year":"2025","journal-title":"American Journal of Physiology\u2010Cell Physiology"},{"issue":"4","key":"e_1_2_5_103_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3390\/cells12040582","article-title":"Transfer of cardiac mitochondria improves the therapeutic efficacy of mesenchymal stem cells in a preclinical model of ischemic heart disease","volume":"12","author":"Vignais M. L.","year":"2023","journal-title":"Cells"},{"issue":"1","key":"e_1_2_5_104_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76219-x","article-title":"Nuclear receptor 4A1 ameliorates UUO\u2010induced renal fibrosis by inhibiting the PI3K\/AKT pathway","volume":"14","author":"Wang H.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_5_105_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2025.113024","article-title":"The rate of force development \u2010 in cat and rat medial gastrocnemius motor units \u2010 an interspecies comparison","volume":"194","author":"Wasicki B.","year":"2025","journal-title":"Journal of Biomechanics"},{"key":"e_1_2_5_106_1","first-page":"21","article-title":"Dynamics of muscle fibre growth during postnatal mouse development","volume":"10","author":"White R. B.","year":"2010","journal-title":"BioMed Central Developmental Biology"},{"issue":"5","key":"e_1_2_5_107_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/jcsm.12316","article-title":"Immunomodulatory placental\u2010expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty","volume":"9","author":"Winkler T.","year":"2018","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"4","key":"e_1_2_5_108_1","doi-asserted-by":"crossref","first-page":"C1017","DOI":"10.1152\/ajpcell.00287.2023","article-title":"Alignment, cross linking, and beyond: A collagen architect's guide to the skeletal muscle extracellular matrix","volume":"325","author":"Wohlgemuth R. P.","year":"2023","journal-title":"American Journal of Physiology\u2010Cell Physiology"},{"issue":"3","key":"e_1_2_5_109_1","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.4238\/2013.September.19.4","article-title":"Analysis of FOS, BTG2, and NR4A in the function of renal medullary hypertension","volume":"12","author":"Wu Y. B.","year":"2013","journal-title":"Genetics and Molecular Research"},{"issue":"1","key":"e_1_2_5_110_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13395-021-00280-7","article-title":"The SarcoEndoplasmic Reticulum calcium ATPase (SERCA) pump: A potential target for intervention in aging and skeletal muscle pathologies","volume":"11","author":"Xu H.","year":"2021","journal-title":"Skeletal Muscle"},{"issue":"4","key":"e_1_2_5_111_1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s12276-024-01199-x","article-title":"Age\u2010dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure","volume":"56","author":"Yoo Y.","year":"2024","journal-title":"Experimental & Molecular Medicine"},{"issue":"3","key":"e_1_2_5_112_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3390\/molecules28031271","article-title":"Identification of a novel angiogenesis signalling circSCRG1\/miR\u20101268b\/NR4A1 pathway in atherosclerosis and the regulatory effects of TMP\u2010PF In vitro","volume":"28","author":"Yuan R.","year":"2023","journal-title":"Molecules"},{"issue":"13","key":"e_1_2_5_113_1","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1016\/j.celrep.2019.05.092","article-title":"Glucose metabolism drives histone acetylation landscape transitions that dictate muscle stem cell function","volume":"27","author":"Yucel N.","year":"2019","journal-title":"Cell Reports"},{"issue":"9","key":"e_1_2_5_114_1","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1038\/s44318-025-00397-1","article-title":"Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation","volume":"44","author":"Yue F.","year":"2025","journal-title":"The European Molecular Biology Organization Journal"},{"issue":"42","key":"e_1_2_5_115_1","article-title":"Mitochondrial transplantation augments the reparative capacity of macrophages following myocardial injury","volume":"12","author":"Zhang Y.","year":"2025","journal-title":"Advanced Science (Weinheim, Baden\u2010Wurttemberg, Germany)"},{"issue":"15","key":"e_1_2_5_116_1","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.7150\/ijbs.95174","article-title":"NR4A3 inhibits the tumor progression of hepatocellular carcinoma by inducing cell cycle G0\/G1 phase arrest and upregulation of CDKN2AIP expression","volume":"20","author":"Zhao X.","year":"2024","journal-title":"International Journal of Biological Sciences"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP290801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP290801","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP290801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:48:25Z","timestamp":1779432505000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP290801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":115,"alternative-id":["10.1113\/JP290801"],"URL":"https:\/\/doi.org\/10.1113\/jp290801","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"JP290801"}}