{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:22:11Z","timestamp":1791555731092,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00NS119739"],"award-info":[{"award-number":["R00NS119739"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"\n Abstract<\/jats:title>\n \n Fast\u2010conducting A\u03b2 slowly adapting type I low threshold mechanoreceptors (SAI\u2010LTMRs) and A\u03b2 rapidly adapting type I (RAI\u2010)LTMRs are critical for discriminative touch from glabrous skin. Recent studies used mouse genetic loss\u2010of\u2010function and optogenetic gain\u2010of\u2010function manipulations to determine that signals from these A\u03b2 LTMRs are integrated subcortically to build the cortical representation of touch. However, the precise influence of each subtype on downstream responses is unclear, in part because previous manipulations lacked the capacity to reproduce physiological firing rates and patterns in individual A\u03b2 LTMR subtypes. Here, we took advantage of a fast variant of channelrhodopsin, CatCh, which enabled us to generate irregular spike trains with mean rates of 20\u00a0Hz in either subtype when monitoring responses in mouse primary somatosensory cortex (S1). Doing so revealed that propagation of steady\u2010state signals from sustained responses of A\u03b2 SAI\u2010LTMRs to neural activity (spiking and local field potential) in S1 is dependent on synchronous activation of multiple A\u03b2 SAI\u2010LTMRs. Asynchronous activation of the same A\u03b2 SAI\u2010LTMRs rarely produced sustained responses in S1 measured at the level of single unit spiking as well as local field potentials. This suggests that the irregular firing patterns of A\u03b2 SAI\u2010LTMRs during static indentations contribute to the preponderance of transient cortical responses. By contrast, both synchronous and asynchronous activation of multiple A\u03b2 RAI\u2010LTMRs resulted in robust S1 responses. Overall, the temporal patterning and synchrony of activity within A\u03b2 LTMR subtypes govern how well their signals propagate through the ascending somatosensory system.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed\u2010light generation of physiological spiking patterns in A\u03b2 low threshold mechanoreceptor (LTMR) subtypes.<\/jats:p>\n <\/jats:list-item>\n \n The synchrony of multiple mechanoreceptors within a subtype controls the extent to which their signals influence activity in primary somatosensory cortex.<\/jats:p>\n <\/jats:list-item>\n \n A\u03b2 rapidly adapting type I (RAI\u2010)LTMRs drive stronger cortical responses than A\u03b2 slowly adapting type I (SAI\u2010)LTMRs, especially when considering asynchronous activation of A\u03b2 LTMRs within each subtype.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp290937","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:25:59Z","timestamp":1786681559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synchrony within A\u03b2 mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4555-1777","authenticated-orcid":false,"given":"Wanyi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cell Biology Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-2675","authenticated-orcid":false,"given":"Andrew E.","family":"Worthy","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Emory University School of Medicine Atlanta Georgia USA"},{"name":"Neuroscience Graduate Program Emory University Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-4263","authenticated-orcid":false,"given":"Alan J.","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"4","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.neuron.2013.07.051","article-title":"The sensory neurons of touch","volume":"79","author":"Abraira V. 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L.","year":"1996","journal-title":"Brain"},{"issue":"7","key":"e_1_2_6_43_1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.cell.2014.11.038","article-title":"The cellular and molecular basis of direction selectivity of a\u03b4\u2010LTMRs","volume":"159","author":"Rutlin M.","year":"2014","journal-title":"Cell"},{"issue":"3","key":"e_1_2_6_44_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuron.2023.10.021","article-title":"Absence of paresthesia during high\u2010rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation","volume":"112","author":"Sagalajev B.","year":"2024","journal-title":"Neuron"},{"issue":"4","key":"e_1_2_6_45_1","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/aa5eea","article-title":"Open Ephys: An open\u2010source, plugin\u2010based platform for multichannel electrophysiology","volume":"14","author":"Siegle J. H.","year":"2017","journal-title":"Journal of Neural Engineering"},{"issue":"4","key":"e_1_2_6_46_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1152\/jn.1984.51.4.724","article-title":"Modular distribution of neurons with slowly adapting and rapidly adapting responses in area 3b of somatosensory cortex in monkeys","volume":"51","author":"Sur M.","year":"1984","journal-title":"Journal of Neurophysiology"},{"issue":"49","key":"e_1_2_6_47_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115772118","article-title":"Sensory computations in the cuneate nucleus of macaques","volume":"118","author":"Suresh A. K.","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"18","key":"e_1_2_6_48_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312992121","article-title":"Chaotic neural dynamics facilitate probabilistic computations through sampling","volume":"121","author":"Terada Y.","year":"2024","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"e_1_2_6_49_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41467-024-45190-6","article-title":"Biomimetic computer\u2010to\u2010brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation","volume":"15","author":"Valle G.","year":"2024","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_6_50_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2018.08.033","article-title":"Biomimetic intraneural sensory feedback enhances sensation naturalness, tactile sensitivity, and manual dexterity in a bidirectional prosthesis","volume":"100","author":"Valle G.","year":"2018","journal-title":"Neuron"},{"issue":"6","key":"e_1_2_6_51_1","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1152\/jn.1999.81.6.2701","article-title":"SA1 and RA receptive fields, response variability, and population responses mapped with a probe array","volume":"81","author":"Vega\u2010Bermudez F.","year":"1999","journal-title":"Journal of Neurophysiology"},{"issue":"20","key":"e_1_2_6_52_1","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1113\/JP276608","article-title":"Specialized mechanoreceptor systems in rodent glabrous skin","volume":"596","author":"Walcher J.","year":"2018","journal-title":"The Journal of Physiology"},{"issue":"4","key":"e_1_2_6_53_1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.cell.2020.04.007","article-title":"The allen mouse brain common coordinate framework: A 3D reference atlas","volume":"181","author":"Wang Q.","year":"2020","journal-title":"Cell"},{"issue":"6","key":"e_1_2_6_54_1","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1152\/jn.00810.2009","article-title":"The regularity of sustained firing reveals two populations of slowly adapting touch receptors in mouse hairy skin","volume":"103","author":"Wellnitz S. 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