{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:45:58Z","timestamp":1777074358727,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL139829"],"award-info":[{"award-number":["R01 HL139829"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2OD028190"],"award-info":[{"award-number":["OT2OD028190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL153114"],"award-info":[{"award-number":["R01HL153114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL158952"],"award-info":[{"award-number":["R01HL158952"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL169877"],"award-info":[{"award-number":["R01HL169877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23IPA1052289"],"award-info":[{"award-number":["23IPA1052289"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23TPA1069000"],"award-info":[{"award-number":["23TPA1069000"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"\n Abstract<\/jats:title>\n \n We previously found that isoproterenol activates apamin\u2010sensitive small\u2010conductance Ca\n 2+<\/jats:sup>\n \u2010activated K\n +<\/jats:sup>\n currents (\n I<\/jats:italic>\n KAS<\/jats:sub>\n ) more in female than male rabbit ventricles. Isoproterenol activates all \u03b2\u2010adrenoceptors (ARs). It remains unknown which AR is responsible for\n I<\/jats:italic>\n KAS<\/jats:sub>\n activation. We studied Langendorff\u2010perfused rabbit hearts with dual optical mapping to determine the action potential duration and intracellular Ca\n 2<\/jats:sup>\n +<\/jats:sup>\n (Ca\n i<\/jats:sub>\n ) during atrial pacing. Study\u00a0I (six females and six males): baseline \u2013 1\u00a0\u00b5\n m<\/jats:sc>\n denopamine (specific \u03b21\u2010AR agonist) \u2013 100\u00a0n\n m<\/jats:sc>\n apamin. Study\u00a0II (seven females and six males): baseline \u2013 pirbuterol 1 or 10\u00a0\u00b5\n m<\/jats:sc>\n (specific \u03b22\u2010AR agonist) \u2013 100\u00a0n\n m<\/jats:sc>\n apamin. Study\u00a0III (three females): baseline \u2013 1\u00a0\u00b5\n m<\/jats:sc>\n mirabegron (specific \u03b23\u2010AR agonist) \u2013 100\u00a0n\n m<\/jats:sc>\n apamin. During denopamine infusion, at a pacing cycle length (PCL) of 200 ms, apamin significantly prolonged action potential duration (APD) at the level of 25% repolarization (APD\n 25<\/jats:sub>\n ) and 80% repolarization (APD\n 80<\/jats:sub>\n ) in female ventricles, but not male ventricles. The Ca\n i<\/jats:sub>\n time\u2010to\u2010peak duration was significantly shortened by denopamine only in females, but not in males. At aPCL of 250\u00a0ms, Ca\n i<\/jats:sub>\n time\u2010to\u2010peak duration was significantly shortened following denopamine administration in both females and males. Subsequent administration of apamin significantly prolonged APD\n 25<\/jats:sub>\n and APD\n 80<\/jats:sub>\n in both females and males in the presence of denopamine. Neither pirbuterol nor mirabegron shortened Ca\n i<\/jats:sub>\n time\u2010to\u2010peak duration. Subsequent administration of apamin did not prolong APD\n 80<\/jats:sub>\n . We conclude that \u03b21\u2010AR, but not \u03b22 or \u03b23\u2010AR, activates\n I<\/jats:italic>\n KAS<\/jats:sub>\n in rabbit ventricles. This rate\u2010dependent effect exhibits a sex difference and is associated with a significant shortening of Ca\n i<\/jats:sub>\n time\u2010to\u2010peak duration.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n \n \u03b21\u2010adrenoceptor (AR) agonist denopamine activates the apamin\u2010sensitive small\u2010conductance Ca\n 2+<\/jats:sup>\n \u2010activated K\n +<\/jats:sup>\n current (\n I<\/jats:italic>\n KAS<\/jats:sub>\n ) in female rabbit ventricles at a pacing cycle length (PCL) of both 200 ms and 250 ms and in male ventricles only at a PCL of 250\u00a0ms.\n <\/jats:p>\n <\/jats:list-item>\n \n \n A significantly shortened time\u2010to\u2010peak of intracellular Ca\n 2+<\/jats:sup>\n (Ca\n i<\/jats:sub>\n ) transient is associated with\n I<\/jats:italic>\n KAS<\/jats:sub>\n activation.\n <\/jats:p>\n <\/jats:list-item>\n \n \n \u03b22\u2010AR agonist pirbuterol and \u03b23\u2010AR agonist mirabegron do not activate\n I<\/jats:italic>\n KAS<\/jats:sub>\n or shorten the Ca\n i<\/jats:sub>\n time\u2010to\u2010peak duration.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1113\/jp291047","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:20:25Z","timestamp":1775017225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex\u2010dependent activation of apamin\u2010sensitive small\u2010conductance Ca\n 2+<\/sup>\n \u2010activated K\n +<\/sup>\n current by \u03b21\u2010adrenergic stimulation in rabbit ventricles"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-6137","authenticated-orcid":false,"given":"Minjing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute Cedars\u2010Sinai Health Sciences University Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7758-0355","authenticated-orcid":false,"given":"Liyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute Cedars\u2010Sinai Health Sciences University Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anxhela","family":"Kote","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute Cedars\u2010Sinai Health Sciences University Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute Cedars\u2010Sinai Health Sciences University Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-9463","authenticated-orcid":false,"given":"James E.","family":"Tisdale","sequence":"additional","affiliation":[{"name":"College of Pharmacy Purdue University Indianapolis Indiana USA"},{"name":"Division of Clinical Pharmacology, Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Thomas H.","family":"Everett","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-9226","authenticated-orcid":false,"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute Cedars\u2010Sinai Health Sciences University Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4150-5836","authenticated-orcid":false,"given":"Peng\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute Cedars\u2010Sinai Health Sciences University Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-physiol-020911-153336","article-title":"Small\u2010conductance Ca2+\u2010activated K+ channels: Form and function","volume":"74","author":"Adelman J. P.","year":"2012","journal-title":"Annual Review of Physiology"},{"issue":"6868","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation\u2010contraction coupling","volume":"415","author":"Bers D. M.","year":"2002","journal-title":"Nature"},{"issue":"2","key":"e_1_2_6_4_1","first-page":"I12","article-title":"Beta\u2010adrenergic pathways in nonfailing and failing human ventricular myocardium","volume":"82","author":"Bristow M. R.","year":"1990","journal-title":"Circulation"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.curtheres.2022.100674","article-title":"Selectivity and maximum response of Vibegron and Mirabegron for beta3\u2010adrenergic receptors","volume":"96","author":"Brucker B. M.","year":"2022","journal-title":"Current Therapeutic Research, Clinical and Experimental"},{"issue":"15","key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/CIRCULATIONAHA.114.015125","article-title":"Small conductance calcium\u2010activated potassium current is activated during hypokalemia and masks short term cardiac memory induced by ventricular pacing","volume":"132","author":"Chan Y.\u2010H.","year":"2015","journal-title":"Circulation"},{"issue":"10","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.hrthm.2013.07.003","article-title":"Apamin induces early afterdepolarizations and Torsades de Pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium","volume":"10","author":"Chang P. C.","year":"2013","journal-title":"Heart Rhythm"},{"issue":"1","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.004713","article-title":"Heterogeneous upregulation of apamin\u2010sensitive potassium currents in failing human ventricles","volume":"2","author":"Chang P. C.","year":"2013","journal-title":"Journal of the American Heart Association"},{"issue":"18","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1113\/JP275681","article-title":"Sex\u2010specific activation of SK current by Isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles","volume":"596","author":"Chen M.","year":"2018","journal-title":"The Journal of Physiology"},{"issue":"9","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1161\/CIRCRESAHA.114.303772","article-title":"Role of the autonomic nervous system in atrial fibrillation: Pathophysiology and therapy","volume":"114","author":"Chen P. S.","year":"2014","journal-title":"Circulation Research"},{"issue":"8","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCRESAHA.110.238386","article-title":"Small\u2010conductance calcium\u2010activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles","volume":"108","author":"Chua S. K.","year":"2011","journal-title":"Circulation Research"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3389\/fphar.2018.00904","article-title":"New insights in cardiac beta\u2010adrenergic signaling during heart failure and aging","volume":"9","author":"Lucia C.","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1113\/jphysiol.1984.sp015436","article-title":"Effects of selective alpha 1\u2010, alpha 2\u2010, beta 1\u2010and beta 2\u2010adrenoceptor stimulation on potentials and contractions in the rabbit heart","volume":"355","author":"Dukes I. D.","year":"1984","journal-title":"The Journal of Physiology"},{"issue":"7","key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI2191","article-title":"The negative inotropic effect of beta3\u2010adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle","volume":"102","author":"Gauthier C.","year":"1998","journal-title":"Journal of Clinical Investigation"},{"issue":"10","key":"e_1_2_6_15_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111411","article-title":"Sex differences in beta\u2010adrenergic responsiveness of action potentials and intracellular calcium handling in isolated rabbit hearts","volume":"9","author":"Hoeker G. S.","year":"2014","journal-title":"PLoS ONE"},{"issue":"2","key":"e_1_2_6_16_1","first-page":"410","article-title":"Apamin\u2010sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles","volume":"6","author":"Hsieh Y. C.","year":"2013","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"11","key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"H1388","DOI":"10.1152\/ajpheart.00665.2015","article-title":"A technical review of optical mapping of intracellular calcium within myocardial tissue","volume":"310","author":"Jaimes R.","year":"2016","journal-title":"American Journal of Physiology\u2010Heart and Circulatory Physiology"},{"issue":"7","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1113\/EP085977","article-title":"Sex and regional differences in rabbit right ventricular L\u2010type calcium current levels and mathematical modelling of arrhythmia vulnerability","volume":"102","author":"Kalik Z. M.","year":"2017","journal-title":"Experimental Physiology"},{"issue":"10","key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/jce.12176","article-title":"Apamin\u2010sensitive calcium\u2010activated potassium currents in rabbit ventricles with chronic myocardial infarction","volume":"24","author":"Lee Y. S.","year":"2013","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"2","key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1469-7793.1998.425bb.x","article-title":"Control of L\u2010type calcium current during the action potential of guinea\u2010pig ventricular myocytes","volume":"513","author":"Linz K. W.","year":"1998","journal-title":"The Journal of Physiology"},{"issue":"9","key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1113\/JP286901","article-title":"Antiarrhythmic effects of mirabegron on ventricular fibrillation in Langendorff\u2010perfused rabbit ventricles","volume":"603","author":"Liu X.","year":"2025","journal-title":"The Journal of Physiology"},{"issue":"2","key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0022-3565(24)37435-X","article-title":"Gender difference in the cycle length\u2010dependent QT and potassium currents in rabbits","volume":"285","author":"Liu X. K.","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0022-3565(25)31437-0","article-title":"Pirbuterol, a selecttve beta2 adrenergic bronchodilator","volume":"207","author":"Moore P. F.","year":"1978","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1254\/jjp.38.235","article-title":"Studies on the affinity and selectivity of denopamine (TA\u2010064), a new cardiotonic agent, for beta\u2010adrenergic receptors","volume":"38","author":"Naito K.","year":"1985","journal-title":"Japanese Journal of Pharmacology"},{"issue":"1","key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13293-017-0148-4","article-title":"Genomic upregulation of cardiac Cav1.2alpha and NCX1 by estrogen in women","volume":"8","author":"Papp R.","year":"2017","journal-title":"Biology of Sex Differences"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.yjmcc.2014.07.006","article-title":"Sex differences in SR Ca2+ release in murine ventricular myocytes are regulated by the cAMP\/PKA pathway","volume":"75","author":"Parks R. J.","year":"2014","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"5","key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"H640","DOI":"10.1152\/ajpheart.00864.2013","article-title":"Sex differences in the mechanisms underlying long QT syndrome","volume":"307","author":"Salama G.","year":"2014","journal-title":"American Journal of Physiology\u2010Heart and Circulatory Physiology"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1756-0500-4-162","article-title":"Selection of reference genes for normalization of quantitative real\u2010time PCR in organ culture of the rat and rabbit intervertebral disc","volume":"4","author":"Seol D.","year":"2011","journal-title":"BMC Research Notes"},{"issue":"6","key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","article-title":"Role of the autonomic nervous system in modulating cardiac arrhythmias","volume":"114","author":"Shen M. J.","year":"2014","journal-title":"Circulation Research"},{"issue":"9","key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1161\/CIRCRESAHA.108.173740","article-title":"Sex, age, and regional differences in L\u2010type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug\u2010induced long QT type 2","volume":"102","author":"Sims C.","year":"2008","journal-title":"Circulation Research"},{"issue":"5","key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"H738","DOI":"10.1152\/ajpheart.00621.2013","article-title":"Sarcoplasmic reticulum Ca2+ release is both necessary and sufficient for SK channel activation in ventricular myocytes","volume":"306","author":"Terentyev D.","year":"2014","journal-title":"American Journal of Physiology\u2010Heart and Circulatory Physiology"},{"issue":"1","key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.hrthm.2020.07.020","article-title":"Sex\u2010specific IKAS activation in rabbit ventricles with drug\u2010induced QT prolongation","volume":"18","author":"Wu A. Z.","year":"2020","journal-title":"Heart Rhythm"},{"issue":"1","key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/01.RES.84.1.43","article-title":"Coupling of beta2\u2010adrenoceptor to gi proteins and its physiological relevance in murine cardiac myocytes","volume":"84","author":"Xiao R. P.","year":"1999","journal-title":"Circulation Research"},{"issue":"3","key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1113\/jphysiol.2011.219501","article-title":"Oestrogen upregulates L\u2010type Ca2+ channels via oestrogen\u2010receptor\u2010 by a regional genomic mechanism in female rabbit hearts","volume":"590","author":"Yang X.","year":"2012","journal-title":"The Journal of Physiology"},{"issue":"11","key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.hrthm.2013.09.021","article-title":"Apamin does not block major cardiac depolarization and repolarization currents","volume":"10","author":"Yu C.\u2010C.","year":"2013","journal-title":"Heart Rhythm"},{"issue":"1","key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1038\/s41598-018-22843-3","article-title":"Coupling of SK channels, L\u2010type Ca2+ channels, and ryanodine receptors in cardiomyocytes","volume":"8","author":"Zhang X. D.","year":"2018","journal-title":"Scientific reports"},{"issue":"6","key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00424-012-1193-9","article-title":"Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits","volume":"465","author":"Zhu Y.","year":"2013","journal-title":"Pflugers Archiv: European Journal of Physiology"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP291047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP291047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP291047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:20:31Z","timestamp":1775017231000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP291047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":36,"alternative-id":["10.1113\/JP291047"],"URL":"https:\/\/doi.org\/10.1113\/jp291047","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"2026-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"JP291047"}}