{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:45:11Z","timestamp":1792147511581,"version":"4.4.0"},"reference-count":157,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["834370"],"award-info":[{"award-number":["834370"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["12\/IA\/1531"],"award-info":[{"award-number":["12\/IA\/1531"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nearly 100\u00a0years ago, Otto Warburg observed that cancer cells preferentially use glycolysis even in the presence of oxygen, supporting rapid cell growth. Since then, the concept of the Warburg effect has expanded far beyond tumour bioenergetics and is now recognised as a key feature of immune cell activation. A notable example is in macrophages, which, following pro\u2010inflammatory stimulation, undergo Warburg\u2010like metabolic reprogramming, characterised by increased glycolysis. Recent studies have shown that accumulated metabolites such as lactate have a range of immunoregulatory functions that shape macrophage inflammatory responses. In addition, glycolytic enzymes have been found to exert non\u2010canonical functions that directly regulate macrophage immune signalling. Mitochondria, once considered suppressed during Warburg reprogramming, also undergo profound changes, with the electron transport chain generating reactive oxygen species and metabolites such as succinate, fumarate and itaconate playing complex immunoregulatory roles, and mitochondrial dynamics actively shaping metabolism and immune responses. Together, these findings redefine the Warburg effect in macrophages as a coordinated metabolic and signalling process that integrates glycolysis, mitochondrial function and immunometabolite signalling to optimise context\u2010dependent immune responses.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp70889-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1113\/jp291073","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:52:22Z","timestamp":1792144342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation"],"prefix":"10.1113","author":[{"given":"Yukun","family":"Min","sequence":"first","affiliation":[{"name":"School of Biochemistry &amp; Immunology Trinity Biomedical Sciences Institute, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7233-2852","authenticated-orcid":false,"given":"\u00d3rlaith C.","family":"Henry","sequence":"additional","affiliation":[{"name":"School of Biochemistry &amp; Immunology Trinity Biomedical Sciences Institute, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4771-6839","authenticated-orcid":false,"given":"Luke A. J.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"School of Biochemistry &amp; Immunology Trinity Biomedical Sciences Institute, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3079"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.015"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102073"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade7652"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108756"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01185-3"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114570"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.012"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.035"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0336-y"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.051"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01224-x"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116336"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2024.07.011"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.12.015"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104561"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414760"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00853-8"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614035114"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2321929121"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"issue":"9","key":"e_1_2_2_23_1","first-page":"1145","article-title":"Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis","volume":"16","author":"Chourasia A. H.","year":"2015","journal-title":"European Molecular Biology Organization Reports"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13490"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00154-5"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-025-01489-5"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.02.028"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156151"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02311-x"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695916"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-062624-013520"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.110"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08187-6"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31031-2"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025490"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.593805"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3509"},{"issue":"1","key":"e_1_2_2_38_1","first-page":"74","article-title":"Effect of metformin versus placebo on metabolic factors in the MA.32 randomized breast cancer trial","volume":"7","author":"Goodwin P. J.","year":"2021","journal-title":"Nature Partner Journal Breast Cancer"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009943"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2263"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10090372"},{"issue":"1","key":"e_1_2_2_42_1","first-page":"97","article-title":"Some biochemical aspects of the immune macrophage","volume":"51","author":"Hard G. C.","year":"1970","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00626-5"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.016"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05720-6"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202510811"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb9818"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009778117"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.005"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2026.01.001"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21186-4"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157727"},{"key":"e_1_2_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102304"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2023.38.S1.5732886"},{"key":"e_1_2_2_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12363"},{"key":"e_1_2_2_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0372-7"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4665"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.246"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.004"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172150"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115350"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116421"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1520814"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23598-8"},{"key":"e_1_2_2_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9932099"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2026.117179"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.05.012"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13078-5"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-026-08708-y"},{"key":"e_1_2_2_70_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160061"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2026.01.003"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.075903"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-026-01414-x"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2475-6"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-65582-6"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218599110"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25986"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0255-3"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201411100"},{"key":"e_1_2_2_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-6930-2_6"},{"key":"e_1_2_2_82_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2390121"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01145-1"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14433-7"},{"key":"e_1_2_2_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.005"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15489"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130996"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01275-0"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.23.10238"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2026.107153"},{"key":"e_1_2_2_91_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S490655"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0323-5"},{"key":"e_1_2_2_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001424"},{"key":"e_1_2_2_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade8701"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114607"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(74)90456-1"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08146-w"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-01076-y"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00605-w"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25445"},{"key":"e_1_2_2_101_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150900"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010181"},{"key":"e_1_2_2_103_1","unstructured":"Sitryx advances development of PKM2 modulator SYX\u20105219 into atopic dermatitis patients following clinical evidence of immunomodulatory activity(2026).Sytrix.https:\/\/www.sitryx.com\/news\/sitryx\u2010advances\u2010development\u2010of\u2010pkm2\u2010modulator\u2010syx\u20105219\u2010into\u2010atopic\u2010dermatitis\u2010patients\u2010following\u2010clinical\u2010evidence\u2010of\u2010immunomodulatory\u2010activity"},{"key":"e_1_2_2_104_1","unstructured":"Sitryx completes enrollment in phase 1b trial of first\u2010in\u2010class oral PKM2 modulator SYX\u20105219 in atopic dermatitis(2026).Sytrix.https:\/\/www.sitryx.com\/news\/sitryx\u2010completes\u2010enrollment\u2010in\u2010phase\u20101b\u2010trial\u2010of\u2010first\u2010in\u2010class\u2010oral\u2010pkm2\u2010modulator\u2010syx\u20105219\u2010in\u2010atopic\u2010dermatitis"},{"key":"e_1_2_2_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01410-x"},{"key":"e_1_2_2_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu4369"},{"key":"e_1_2_2_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.01.028"},{"key":"e_1_2_2_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04270-9"},{"key":"e_1_2_2_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12091255"},{"key":"e_1_2_2_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54377-w"},{"key":"e_1_2_2_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103529"},{"key":"e_1_2_2_112_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900887RR"},{"key":"e_1_2_2_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0210-0"},{"key":"e_1_2_2_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149050"},{"key":"e_1_2_2_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"},{"key":"e_1_2_2_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115172"},{"key":"e_1_2_2_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108079"},{"key":"e_1_2_2_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.008"},{"key":"e_1_2_2_119_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278810"},{"key":"e_1_2_2_120_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.75434"},{"key":"e_1_2_2_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320488"},{"key":"e_1_2_2_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01503-7"},{"key":"e_1_2_2_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03591-5"},{"key":"e_1_2_2_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02253-23"},{"key":"e_1_2_2_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100904"},{"key":"e_1_2_2_126_1","first-page":"317","article-title":"Tests on surviving carcinoma cultures","volume":"142","author":"Warburg O.","year":"1923","journal-title":"Biochemische Zeitschrift"},{"key":"e_1_2_2_127_1","doi-asserted-by":"publisher","DOI":"10.1158\/jcr.1925.148"},{"key":"e_1_2_2_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00791-9"},{"key":"e_1_2_2_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09973"},{"key":"e_1_2_2_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109977"},{"key":"e_1_2_2_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.076"},{"key":"e_1_2_2_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2026.116258"},{"key":"e_1_2_2_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110104"},{"key":"e_1_2_2_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114148"},{"key":"e_1_2_2_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00631-8"},{"key":"e_1_2_2_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.10.002"},{"key":"e_1_2_2_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02957-1"},{"key":"e_1_2_2_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00841-9"},{"key":"e_1_2_2_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.05.039"},{"key":"e_1_2_2_140_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5766434"},{"key":"e_1_2_2_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70450"},{"key":"e_1_2_2_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.595316"},{"key":"e_1_2_2_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07227-w"},{"key":"e_1_2_2_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101761"},{"key":"e_1_2_2_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69388-y"},{"key":"e_1_2_2_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fddsv.2023.1294454"},{"key":"e_1_2_2_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_2_2_148_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1787"},{"key":"e_1_2_2_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"issue":"5","key":"e_1_2_2_150_1","first-page":"1069","article-title":"Activation of NLRP3 inflammasome via Drp1 overexpression in Kupffer cells aggravates ischemia\u2010reperfusion injury in hepatic steatosis","volume":"11","author":"Zhang L.","year":"2023","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_2_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114180"},{"key":"e_1_2_2_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.05.009"},{"key":"e_1_2_2_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-025-00657-4"},{"key":"e_1_2_2_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13622"},{"key":"e_1_2_2_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-67473-2"},{"key":"e_1_2_2_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02926-8"},{"key":"e_1_2_2_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.03.048"},{"key":"e_1_2_2_158_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq7307"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP291073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/JP291073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP291073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:52:25Z","timestamp":1792144345000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP291073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":157,"alternative-id":["10.1113\/JP291073"],"URL":"https:\/\/doi.org\/10.1113\/jp291073","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"2026-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"JP291073"}}