{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:30:37Z","timestamp":1771623037974,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1966,6,1]],"date-time":"1966-06-01T00:00:00Z","timestamp":-113184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1966,6]]},"abstract":"<jats:p>1. In albino rats the botulinum poisoned gastrocnemius muscle was supplied with an accessory motor nerve in order to investigate whether muscle fibres with structurally intact but non\u2010transmitting synapses would accept additional innervation. As a control similar operations were made in unpoisoned rats.<\/jats:p><jats:p>2. One to three months after nerve implantation the muscles were examined histologically for the presence of a new end\u2010plate zone. In botulinum treated muscles 1662 \u00b1 165 (mean \u00b1 \n<jats:sc>S.D.<\/jats:sc>) of new end\u2010plates were found. In the control animals only a few (90 \u00b1 13) were observed in the immediate vicinity of the implanted nerve trunk.<\/jats:p><jats:p>3. Following recovery from the paralysing action of botulinum toxin electrical stimulation of both the implanted and the original motor nerve evoked strong mechanical twitches in the gastrocnemius muscle.<\/jats:p><jats:p>4. When the nerves were stimulated simultaneously little or no summation of tension occurred, indicating that presumably many of the muscle fibres with new end\u2010plates also had functionally intact junctions from the original nerve. The presence of two end\u2010plates in a muscle fibre was confirmed in a few experiments on single curarized fibres by intracellular recording of end\u2010plate potentials on stimulation of each nerve.<\/jats:p>","DOI":"10.1113\/jphysiol.1966.sp007953","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T01:48:17Z","timestamp":1419040097000},"page":"872-882","source":"Crossref","is-referenced-by-count":62,"title":["Nerve implants in botulinum poisoned mammalian muscle"],"prefix":"10.1113","volume":"184","author":[{"given":"S.","family":"Fex","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sonesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Thesleff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jirina","family":"Zelen\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1966,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1966.sp007953","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1966.sp007953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:13:45Z","timestamp":1699460025000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1966.sp007953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,6]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1966,6]]}},"alternative-id":["10.1113\/jphysiol.1966.sp007953"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1966.sp007953","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,6]]}}}