{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:43:20Z","timestamp":1771645400057,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1966,7,1]],"date-time":"1966-07-01T00:00:00Z","timestamp":-110592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1966,7]]},"abstract":"<jats:p>1. Methods are described for measuring tidal volume and frequency, end\u2010tidal CO<jats:sub>2<\/jats:sub>, blood pressure and heart rate, and arterial gas tensions in the unanaesthetized new\u2010born lamb.<\/jats:p><jats:p>2. The resting values of minute ventilation (<jats:italic>V\u0307<\/jats:italic>)\/kg body wt. and arterial oxygen and carbon dioxide tension, (<jats:italic>P<\/jats:italic><jats:sub>a, o2<\/jats:sub>) and (<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub>) were similar to those which have been reported in the new\u2010born baby. There was a direct and significant relation between <jats:italic>P<\/jats:italic><jats:sub>a, o2<\/jats:sub> and <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub> and the age of the lamb.<\/jats:p><jats:p>3. Thirty\u2010five unanaesthetized lambs aged 40 min to 10 days breathed 100% oxygen; minute ventilation fell by an average of 19% of control, end\u2010tidal CO<jats:sub>2<\/jats:sub> increased and the ratio of change in tidal volume (\u0394<jats:italic>V<jats:sub>T<\/jats:sub><\/jats:italic>) to change in pressure (\u0394<jats:italic>P<\/jats:italic>) (\u0394<jats:italic>V<jats:sub>T<\/jats:sub><\/jats:italic>\/\u0394<jats:italic>P<\/jats:italic>) remained constant. In a proportion of lambs, a small decrease in blood pressure and heart rate was observed. The effect of breathing 100% O<jats:sub>2<\/jats:sub> on lung compliance was variable.<\/jats:p><jats:p>4. These changes in ventilation were virtually abolished after both sinus nerves had been cut.<\/jats:p><jats:p>5. The results therefore suggest that a significant hypoxic drive to ventilation exists in the new\u2010born lamb and that this drive is mediated by functioning and mature peripheral chemoreceptors.<\/jats:p><jats:p>6. Preliminary evidence suggested that, on 100% O<jats:sub>2<\/jats:sub>, the sensitivity of new\u2010born lambs to inhaled CO<jats:sub>2<\/jats:sub> was reduced.<\/jats:p>","DOI":"10.1113\/jphysiol.1966.sp007971","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T02:10:32Z","timestamp":1419041432000},"page":"42-59","source":"Crossref","is-referenced-by-count":17,"title":["Respiratory and circulatory effects of breathing 100% oxygen in the new\u2010born lamb before and after denervation of the carotid chemoreceptors*"],"prefix":"10.1113","volume":"185","author":[{"given":"M. J.","family":"Purves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1966,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1966.sp007971","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1966.sp007971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:27:57Z","timestamp":1699450077000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1966.sp007971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1966,7]]}},"alternative-id":["10.1113\/jphysiol.1966.sp007971"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1966.sp007971","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,7]]}}}