{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:31:31Z","timestamp":1789558291212,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1966,7,1]],"date-time":"1966-07-01T00:00:00Z","timestamp":-110592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1966,7]]},"abstract":"<jats:p>1. Twenty\u2010seven unanaesthetized new\u2010born lambs, 6 hr\u201010 days old, responded to two levels of inspired oxygen, 125 and 110 mm Hg (alveolar CO<jats:sub>2<\/jats:sub> being controlled) with a sustained increase in minute ventilation (<jats:italic>V\u0307<\/jats:italic>), a small increase in heart rate and a less consistent rise in systemic blood pressure.<\/jats:p><jats:p>2. An increase in <jats:italic>V\u0307<\/jats:italic> was observed when arterial oxygen tension (<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub>) had fallen by 6\u201015 mm Hg. There appeared to be no fixed threshold of <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub> at which ventilation started to increase.<\/jats:p><jats:p>3. The increase in ventilation caused by these levels of hypoxia was significantly and directly related to the age of the lamb and to its control alveolar CO<jats:sub>2<\/jats:sub>.<\/jats:p><jats:p>4. More severe hypoxia caused a progressive increase in <jats:italic>V\u0307<\/jats:italic> until <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub> was about 25 mm Hg when respiration failed. This increase at <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub> &gt; 25 mm Hg was markedly potentiated when alveolar <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic><jats:sub>A<\/jats:sub>, CO<jats:sub>2<\/jats:sub>) was increased and abolished after bilateral denervation of the carotid chemoreceptors.<\/jats:p><jats:p>5. Significant (&gt; 10%) left\u2010to\u2010right shunts were found in ten out of twelve lambs lightly anaesthetized with pentobarbitone sodium, breathing air. Hypoxia diminished the left\u2010to\u2010right pressure gradient largely by its pressor effect on the pulmonary circulation. When inspired O<jats:sub>2<\/jats:sub> tension (<jats:italic>P<\/jats:italic><jats:sub>I<\/jats:sub>, O<jats:sub>2<\/jats:sub>) was 70 mm Hg, all seven lambs studied showed a reversal of the pressure gradient and evidence of right\u2010to\u2010left shunts (11\u201042%) across the ductus arteriosus.<\/jats:p><jats:p>6. The implications of these findings have been discussed with reference to previous studies of the new\u2010born response to hypoxia and it is concluded that the peripheral chemoreceptors are fully active at birth and in the new\u2010born period.<\/jats:p>","DOI":"10.1113\/jphysiol.1966.sp007972","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T02:10:32Z","timestamp":1419041432000},"page":"60-77","source":"Crossref","is-referenced-by-count":34,"title":["The effects of hypoxia in the new\u2010born lamb before and after denervation of the carotid chemoreceptors*"],"prefix":"10.1113","volume":"185","author":[{"given":"M. J.","family":"Purves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1966,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1966.sp007972","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1966.sp007972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:28:02Z","timestamp":1699450082000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1966.sp007972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1966,7]]}},"alternative-id":["10.1113\/jphysiol.1966.sp007972"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1966.sp007972","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,7]]}}}