{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:31:04Z","timestamp":1762079464086},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1966,7,1]],"date-time":"1966-07-01T00:00:00Z","timestamp":-110592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1966,7]]},"abstract":"<jats:p>1. The respiratory response to inhaled CO<jats:sub>2<\/jats:sub> was measured in twenty unanaesthetized new\u2010born lambs aged 4 hr\u201010 days. Measurement of resting arterial pH, <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> and plasma bicarbonate showed a non\u2010respiratory acidosis immediately after birth which was corrected in the first 24\u201028 hr: thereafter, the acid\u2014base pattern was of a compensated respiratory alkalosis.<\/jats:p><jats:p>2. When CO<jats:sub>2<\/jats:sub> was added to the inspired gases and resting arterial oxygen tension (<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub>) was controlled, the average increase in minute ventilation (<jats:italic>V\u0307<\/jats:italic>) was 0\u00b7075 l.min<jats:sup>\u22121<\/jats:sup>.kg<jats:sup>\u22121<\/jats:sup>.mm Hg, <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub><jats:sup>\u22121<\/jats:sup> and duplicate responses in the same lamb differed by 6\u201022\u00b75%.<\/jats:p><jats:p>3. The slope of the <jats:italic>V\u0307<\/jats:italic>\/<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub> line (S) varied inversely with <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub>. In one lamb, severe hypoxia (<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub> = 21 mm Hg) caused a marked depression of the slope.<\/jats:p><jats:p>4. Neither the slope S nor the horizontal intercept B of the lines was related to the age of the lamb. B was not related to pH<jats:sub>a<\/jats:sub> and only slightly affected by acute hypoxia. B was related to arterial [HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>] and values for both were reduced with the acid\u2014base disturbances seen in the first 10 days after birth. Evidence was given which suggested that the response of the new\u2010born lamb to inhaled CO<jats:sub>2<\/jats:sub> was similar to that of man acclimatized to a <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, O<jats:sub>2<\/jats:sub> of 70\u201075 mm Hg.<\/jats:p><jats:p>5. In the lightly anaesthetized lamb, bilateral section of the sinus nerves caused a small reduction in the sensitivity to inhaled 5% CO<jats:sub>2<\/jats:sub> in air, an increase in the respiratory lag and a reduction in the rate at which <jats:italic>V\u0307<\/jats:italic> increased.<\/jats:p><jats:p>6. It was concluded that, in the new\u2010born lamb, the carotid chemo\u2010receptors are involved in the response to inhaled CO<jats:sub>2<\/jats:sub> and that hypoxia potentiates this response.<\/jats:p>","DOI":"10.1113\/jphysiol.1966.sp007973","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T02:10:32Z","timestamp":1419041432000},"page":"78-94","source":"Crossref","is-referenced-by-count":21,"title":["The respiratory response of the new\u2010born lamb to inhaled CO<sub>2<\/sub> with and without accompanying hypoxia*"],"prefix":"10.1113","volume":"185","author":[{"given":"M. J.","family":"Purves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1966,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1966.sp007973","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1966.sp007973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:28:13Z","timestamp":1699450093000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1966.sp007973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1966,7]]}},"alternative-id":["10.1113\/jphysiol.1966.sp007973"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1966.sp007973","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,7]]}}}