{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:33:35Z","timestamp":1771623215726,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1966,7,1]],"date-time":"1966-07-01T00:00:00Z","timestamp":-110592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1966,7]]},"abstract":"<jats:p>1. A study was made of the responses of the isolated taenia of the guinea\u2010pig caecum to stimulation of the intramural nerves.<\/jats:p><jats:p>2. Four types of response are described, made up of a contraction and\/or a relaxation occurring during stimulation and an after\u2010contraction occurring when stimulation is stopped.<\/jats:p><jats:p>3. A delayed relaxation which sometimes occurred at the end of stimulation is also described.<\/jats:p><jats:p>4. Atropine usually abolished the contractions occurring during stimulation. After\u2010contractions either appeared or were increased in amplitude in the presence of atropine, and delayed relaxations were abolished.<\/jats:p><jats:p>5. The anti\u2010cholinesterase drug neostigmine could convert the response during stimulation from a relaxation to a contraction. After\u2010contractions were often abolished by neostigmine and delayed relaxations appeared.<\/jats:p><jats:p>6. It is concluded that the contractions which occurred during stimulation were mediated by cholinergic nerves. The after\u2010contraction appears to be a rebound phenomenon, following the hyperpolarization of the muscle caused by stimulation of the inhibitory nerves. It is suggested that the delayed relaxation is caused by the effects of persisting inhibitory transmitter substance on cells which do not undergo rebound excitation.<\/jats:p>","DOI":"10.1113\/jphysiol.1966.sp007977","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T02:10:32Z","timestamp":1419041432000},"page":"148-159","source":"Crossref","is-referenced-by-count":54,"title":["Nerve\u2010mediated excitation of the taenia of the guinea\u2010pig caecum"],"prefix":"10.1113","volume":"185","author":[{"given":"G.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1966,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1966.sp007977","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1966.sp007977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:28:12Z","timestamp":1699450092000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1966.sp007977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1966,7]]}},"alternative-id":["10.1113\/jphysiol.1966.sp007977"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1966.sp007977","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,7]]}}}