{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:59:02Z","timestamp":1789948742163,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1966,11,1]],"date-time":"1966-11-01T00:00:00Z","timestamp":-99964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1966,11]]},"abstract":"<jats:p>1. Experiments were performed to determine whether intercalated disks represent a high or a low resistance to the diffusion of K ions.<\/jats:p><jats:p>2. Bundles of sheep ventricular fibres, 0\u00b76\u20100\u00b78 mm thick and 7\u201011 mm long, were pulled through a hole in a partition. One half was charged by radiopotassium (K<jats:sup>*<\/jats:sup>); the other half was washed by inactive Tyrode solution.<\/jats:p><jats:p>3. A steady state with respect to the distribution of K<jats:sup>*<\/jats:sup> along the bundle was reached 6 hr after the exposure to radioactivity.<\/jats:p><jats:p>4. On the \u2018washed\u2019 side [K<jats:sup>*<\/jats:sup>] fell along a relatively smooth curve and did not tend to the value zero towards the cut end of the bundle. The average space constant for the decrease of [K<jats:sup>*<\/jats:sup>] was 1\u00b755 mm, corresponding to a distance of about 12 \u00d7 the length of a cell. This indicates that the disk resistance is low and that the fibres are healed over at their cut ends.<\/jats:p><jats:p>5. Rhythmical contraction had no detectable effect on the space constant. This may mean either that shortening and thickening of a cell does not effectively mix its content, or that stirring goes on even in resting cells.<\/jats:p><jats:p>6. On the assumption of mixing between disks the average resistance of 1 cm<jats:sup>2<\/jats:sup> of disk to the movement of K ions is 3 \u03a9. If there is no mixing this value would be even lower.<\/jats:p><jats:p>7. The assumption that K<jats:sup>*<\/jats:sup> distribution within the \u2018washed\u2019 half of the bundle is a consequence of cell\u2010to\u2010cell rather than of extracellular movement is supported by the results of several control experiments.<\/jats:p><jats:p>8. It is concluded that the propagation of the cardiac action potential is possible by local circuit currents.<\/jats:p>","DOI":"10.1113\/jphysiol.1966.sp008092","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T02:31:24Z","timestamp":1419042684000},"page":"323-342","source":"Crossref","is-referenced-by-count":213,"title":["The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle"],"prefix":"10.1113","volume":"187","author":[{"given":"Silvio","family":"Weidmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Hodgkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1966,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1966.sp008092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1966.sp008092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T11:34:00Z","timestamp":1699443240000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1966.sp008092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,11]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1966,11]]}},"alternative-id":["10.1113\/jphysiol.1966.sp008092"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1966.sp008092","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,11]]}}}