{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:20:16Z","timestamp":1761744016411},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1967,1,1]],"date-time":"1967-01-01T00:00:00Z","timestamp":-94694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:p>1. Type A or type D <jats:italic>botulinum<\/jats:italic> toxin administered to rats did not produce a generalized paralysis of skeletal muscles at the time of ventilatory arrest. However, if survival was extended by artificial ventilation complete blockade of neuromuscular transmission developed 6\u00b75 hr after 100 MLD of type D and 5 hr after 1000 MLD of type A toxin. The onset of paralysis of a muscle was shortened by repetitive stimulation of the motor nerves.<\/jats:p><jats:p>2. There was no consistent blockade of parasympathetically innervated viscera in animals dying after type A toxin. Animals given type D toxin displayed mydriasis and urinary retention before death.<\/jats:p><jats:p>3. Motor responses to electrical stimulation, of bladder preparations <jats:italic>in vitro<\/jats:italic> were more vulnerable to type D than to type A toxin. When somatic paralysis was complete in animals treated with type A or type D toxin the excised bladders produced pressure elevations 45 and 25%, respectively, of control preparations.<\/jats:p><jats:p>4. During electrical stimulation of bladder preparations nearly paralysed by either toxin, the ACh release was significantly diminished from controls. In the rat bladder <jats:italic>botulinum<\/jats:italic> toxin specifically disrupted the liberation of mediator from post\u2010ganglionic nerve endings.<\/jats:p>","DOI":"10.1113\/jphysiol.1967.sp008119","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T01:11:22Z","timestamp":1419037882000},"page":"1-11","source":"Crossref","is-referenced-by-count":51,"title":["Motor responses of the urinary bladder and skeletal muscle in <i>Botulinum<\/i> intoxicated rats"],"prefix":"10.1113","volume":"188","author":[{"given":"F. G.","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1967,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1967.sp008119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1967.sp008119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T14:43:00Z","timestamp":1699454580000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1967.sp008119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1967,1]]}},"alternative-id":["10.1113\/jphysiol.1967.sp008119"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1967.sp008119","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,1]]}}}