{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:34:24Z","timestamp":1699490064489},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1967,4,1]],"date-time":"1967-04-01T00:00:00Z","timestamp":-86918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1967,4]]},"abstract":"<jats:p>1. The 24 hourly excretion of pyruvate and glucose has been measured in alloxan\u2010diabetic rats.<\/jats:p><jats:p>2. The animals were allowed a 6\u2010day control period before being injected with alloxan (\n<jats:sc>I.V.<\/jats:sc> 50 mg\/kg body weight). The diabetes was treated by daily injections of insulin for a period of 6 days from the 7th to the 12th day following the alloxan injection.<\/jats:p><jats:p>3. The pyruvate excretion increased more than 5\u2010fold following the induction of diabetes, the values being 189 \u00b1 130 (\n<jats:sc>S.D.<\/jats:sc>) \u03bcg\/24 hr in the control period rising to an average of 1002 \u00b1 664 (\n<jats:sc>S.D.<\/jats:sc>) \u03bcg\/24 hr over the first 6 days of diabetes. The administration of insulin over the second 6\u2010day period of diabetes caused the pyruvate excretion to decrease\u2014though not significantly. Upon the withdrawal of the insulin treatment the pyruvate excretion increased significantly from 785 \u00b1 315 (\n<jats:sc>S.D.<\/jats:sc>) \u03bcg\/24 hr to 2105 \u00b1 679 (\n<jats:sc>S.D.<\/jats:sc>) \u03bcg\/24 hr, measured over a 5\u2010day period. The final period of pyruvate excretion was significantly greater than the excretion over the first diabetic period.<\/jats:p><jats:p>4. The glucose excretion during the initial diabetic period was 6\u00b775 \u00b1 2\u00b764 (\n<jats:sc>S.D.<\/jats:sc>) g\/24 hr. The administration of insulin caused a 42% decrease in glucose excretion compared to a decrease of 22% for the pyruvate. The withdrawal of insulin caused the glucose excretion to increase by 149% while the pyruvate excretion increased by 157%.<\/jats:p><jats:p>5. Diabetes was also induced temporarily by injections of anti\u2010insulin serum and diazoxide. In each case significant glycosuria and hyperpyruvaturia were produced.<\/jats:p><jats:p>6. The possible causes of the hyperpyruvaturia in diabetes are discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1967.sp008165","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T14:56:32Z","timestamp":1419000992000},"page":"237-246","source":"Crossref","is-referenced-by-count":1,"title":["Hyperpyruvaturia in experimental diabetes"],"prefix":"10.1113","volume":"189","author":[{"given":"J.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Coulson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W. S.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1967,4]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1967.sp008165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1967.sp008165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:50:01Z","timestamp":1699451401000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1967.sp008165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1967,4]]}},"alternative-id":["10.1113\/jphysiol.1967.sp008165"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1967.sp008165","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,4]]}}}