{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:07:04Z","timestamp":1771628824442,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1967,6,1]],"date-time":"1967-06-01T00:00:00Z","timestamp":-81648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1967,6]]},"abstract":"<jats:p>1. The activity in carotid body chemoreceptor afferent fibres in the cat has been recorded and found to have a rhythm with the same period as respiration.<\/jats:p><jats:p>2. This rhythm is not an artifact; it is not due to arterial pressure changes with respiration nor to cyclical changes in pulmonary venous admixture. It is caused by changes in blood gas tensions during each respiratory cycle.<\/jats:p><jats:p>3. The amplitude of the rhythm is modified by transient and long\u2010term changes in inspired oxygen or CO<jats:sub>2<\/jats:sub> so that a rise or fall in O<jats:sub>2<\/jats:sub> or CO<jats:sub>2<\/jats:sub> tensions of arterial blood (<jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub>, <jats:italic>P<\/jats:italic><jats:sub>a,CO2<\/jats:sub>) from the physiological range reduces it. The ratio of the rhythm amplitude to the mean rate of chemoreceptor discharge increases with <jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub> over the range 40\u2010240 mm Hg.<\/jats:p><jats:p>4. The rhythm is modified by changes in respiratory frequency and volume.<\/jats:p><jats:p>5. The fluctuations of arterial oxygen tension which have the same period as respiration are shown to be conducted up the vertebral artery at least as far as the vertebro\u2010occipital anastomosis.<\/jats:p><jats:p>6. It is proposed that the chemoreceptor rhythm reflects the moment to moment changes in blood gas tensions.<\/jats:p>","DOI":"10.1113\/jphysiol.1967.sp008217","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T20:26:21Z","timestamp":1419020781000},"page":"389-412","source":"Crossref","is-referenced-by-count":61,"title":["Observations on the rhythmic variation in the cat carotid body chemoreceptor activity which has the same period as respiration"],"prefix":"10.1113","volume":"190","author":[{"given":"T. J.","family":"Biscoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Purves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1967,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1967.sp008217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1967.sp008217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T20:55:04Z","timestamp":1699476904000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1967.sp008217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1967,6]]}},"alternative-id":["10.1113\/jphysiol.1967.sp008217"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1967.sp008217","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,6]]}}}