{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:53:09Z","timestamp":1758405189426},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1968,4,1]],"date-time":"1968-04-01T00:00:00Z","timestamp":-55296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1968,4]]},"abstract":"<jats:p>1. Observations were made on the daily intake and excretion of potassium and sodium in sheep housed in metabolism cages and fed once daily.<\/jats:p><jats:p>2. The diet of chaffed hay and crushed oats provided 400\u2010600 m\u2010moles K and 50\u201060 m\u2010moles Na daily. About 90% of the K was excreted in the urine, and over 90% of the Na was found in the faeces.<\/jats:p><jats:p>3. In two groups of three experiments on each of three sheep, the urinary responses to intra\u2010ruminal dosing just before feeding of (i) 1 l. distilled water, (ii) 1 l. 0\u00b725 \n<jats:sc>N<\/jats:sc>\u2010KCl, and (iii) 1 l. 0\u00b7125 \n<jats:sc>N<\/jats:sc>\u2010NaCl, were studied. In the first group, urine was collected via the urine\/faeces separator of the metabolism cage, whereas for part of the experiments in the second group it was collected by an indwelling bladder catheter.<\/jats:p><jats:p>4. In a third group of experiments with the same sheep, the effects on urinary excretion of K and Na of intra\u2010ruminal dosing with (i) 1 l. distilled water, (ii) 1 l. 0\u00b725 \n<jats:sc>N<\/jats:sc>\u2010K acetate, and (iii) 1 l. 0\u00b725 \n<jats:sc>N<\/jats:sc>\u2010Na acetate were investigated. During part of these experiments urine was again collected via an indwelling bladder catheter. With chloride, 82% of the additional potassium was excreted in urine in the 24 hr after dosing, but with acetate only 65%. For sodium, the corresponding figures were 12\u201040% with chloride and 43% with acetate.<\/jats:p><jats:p>5. In most experiments, the administration of K salts produced a marked kaliuresis and, in spite of the low sodium intake, a natriuresis as well, which did not usually coincide with maximum K excretion. No adequately tested explanation appears to exist for the natriuresis observed in response to treatment with K salts.<\/jats:p>","DOI":"10.1113\/jphysiol.1968.sp008476","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T12:12:21Z","timestamp":1418991141000},"page":"609-621","source":"Crossref","is-referenced-by-count":14,"title":["Renal excretion of potassium in the sheep"],"prefix":"10.1113","volume":"195","author":[{"given":"J. K.","family":"Dewhurst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Keynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1968,4]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1968.sp008476","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1968.sp008476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T20:54:50Z","timestamp":1699476890000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1968.sp008476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1968,4]]}},"alternative-id":["10.1113\/jphysiol.1968.sp008476"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1968.sp008476","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,4]]}}}