{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:05:00Z","timestamp":1772759100476,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1968,7,1]],"date-time":"1968-07-01T00:00:00Z","timestamp":-47433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1968,7]]},"abstract":"<jats:p>1. Intravenous infusions of adrenaline and noradrenaline in doses averaging 0\u00b78 \u03bcg\/kg.min increased the respiratory minute volume of anaesthetized cats breathing room air. The mean increase in respiratory minute volume was 14% during adrenaline infusion and 8% during noradrenaline infusion.<\/jats:p><jats:p>2. In a small group of decerebrate cats infusions of adrenaline and noradrenaline increased ventilation by 19 and 27% respectively.<\/jats:p><jats:p>3. Intravenous catecholamine infusions also increased the respiratory responses of anaesthetized animals to the inhalation of 5% or 10% O<jats:sub>2<\/jats:sub> in N<jats:sub>2<\/jats:sub> and to the inhalation of 5% CO<jats:sub>2<\/jats:sub> in air.<\/jats:p><jats:p>4. Adrenaline and noradrenaline infusions had no significant effect on the ventilation of animals breathing 100% O<jats:sub>2<\/jats:sub>, nor did they significantly alter the respiratory response to the inhalation of 5% CO<jats:sub>2<\/jats:sub> in O<jats:sub>2<\/jats:sub>.<\/jats:p><jats:p>5. After section of the carotid sinus and aortic nerves, a blood\u2010pressure compensator being used to minimize changes in arterial pressure, catecholamines had no effect on the respiration of cats breathing air.<\/jats:p><jats:p>6. An increase in carotid body chemoreceptor discharge accompanied the increase in ventilation during catecholamine infusion.<\/jats:p><jats:p>7. Intravenous catecholamine infusions still produced an increase in ventilation and carotid body chemoreceptor discharge after both aortic nerves and both cervical sympathetic nerves had been cut.<\/jats:p><jats:p>8. Intra\u2010arterial infusions into one carotid artery of 0\u00b72 \u03bcg\/kg.min of adrenaline or 0\u00b71 \u03bcg\/kg.min of noradrenaline led to mean increases in respiratory minute volume of 9\u00b79 and 11\u00b75% respectively. No increase occurred after section of the corresponding carotid sinus nerve. Such infusions also evoked an increase in carotid body chemoreceptor discharge.<\/jats:p><jats:p>9. It is concluded that the hyperpnoea produced by adrenaline and noradrenaline infusions in the cat is predominantly reflex in origin and is mediated by the arterial chemoreceptors.<\/jats:p><jats:p>10. The increase in ventilation produced by adrenaline appears to have a component additional to its effect upon the chemoreceptors though the nature of this action has not been identified.<\/jats:p>","DOI":"10.1113\/jphysiol.1968.sp008541","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T12:28:11Z","timestamp":1418992091000},"page":"1-23","source":"Crossref","is-referenced-by-count":54,"title":["The contribution of the arterial chemoreceptors to the stimulation of respiration by adrenaline and noradrenaline in the cat"],"prefix":"10.1113","volume":"197","author":[{"given":"N.","family":"Joels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1968,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1968.sp008541","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1968.sp008541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T15:27:47Z","timestamp":1699457267000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1968.sp008541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1968,7]]}},"alternative-id":["10.1113\/jphysiol.1968.sp008541"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1968.sp008541","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,7]]}}}