{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:08:24Z","timestamp":1790939304230,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1969,7,1]],"date-time":"1969-07-01T00:00:00Z","timestamp":-15897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1969,7]]},"abstract":"<jats:p>1. Measurements of evaporative sweat loss were made on fifty\u2010six premature and full\u2010term babies 1\u201067 days after birth with an infra\u2010red analyser and a ventilated capsule placed on the thigh. Measurements were also made of total evaporative water loss while in a closed metabolic chamber and of the regional distribution of sweating with starch\u2014iodine paper.<\/jats:p><jats:p>2. No sweating to thermal stimuli could be detected in infants of less than 210 days post\u2010conceptual age, even when rectal temperature rose as high as 37\u00b78\u00b0 C. In older infants sweat was detected first on the forehead and temple, later on the chest, and usually by 240\u2013260 days post\u2010conceptual age on the legs (term \u223c 268 days). Generalized sweating on the limbs appeared at an earlier post\u2010conceptual age in the more prematurely born infants.<\/jats:p><jats:p>3. The response of sweat glands on the thigh to an intradermal injection of 2 \u03bcg acetylcholine (ACh) was tested. No sweat response was detected in infants under 225 days post\u2010conceptual age, while all infants born within 2 weeks of term responded. The response was often augmented after 2\u20105 tests at 5\u201010 min intervals; all the eight infants born within 2 weeks of term who were examined twice in the first 2 weeks of life showed a greater response on the second occasion.<\/jats:p><jats:p>4. An average of 414 active sweat glands\/cm<jats:sup>2<\/jats:sup> were detected on the thigh in eight babies 7\u201310 days old born within 2 weeks of term. This was 6\u00bd times the number found in adults. The mean peak sweat rate to chemical stimulation was however only 2\u00b74 nl.\/gland.min, which was 3 times lower than the maximum rate recorded in adults.<\/jats:p><jats:p>5. In five infants with congenital defects of the brain and complete absence of temperature control there was no sweat response to thermal or direct chemical stimulation of the glands.<\/jats:p><jats:p>6. Functional maturation appears to depend on intact central innervation and is marginally hastened by post\u2010natal factors. Immaturity of the sweat glands can account for the lack of any response to thermal stimuli in premature babies, but not for the modest thermal response obtained in babies at term.<\/jats:p>","DOI":"10.1113\/jphysiol.1969.sp008846","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:58:35Z","timestamp":1418990315000},"page":"13-29","source":"Crossref","is-referenced-by-count":69,"title":["The response of the sweat glands of the new\u2010born baby to thermal stimuli and to intradermal acetylcholine"],"prefix":"10.1113","volume":"203","author":[{"given":"K. G.","family":"Foster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. N.","family":"Hey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1969,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1969.sp008846","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1969.sp008846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T19:59:05Z","timestamp":1699473545000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1969.sp008846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1969,7]]}},"alternative-id":["10.1113\/jphysiol.1969.sp008846"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1969.sp008846","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,7]]}}}