{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:47:40Z","timestamp":1773420460798,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1969,12,1]],"date-time":"1969-12-01T00:00:00Z","timestamp":-2678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1969,12]]},"abstract":"<jats:p>1. A method is described employing a whole\u2010body counter and a miniature GM counter placed within the lumen of the gut which can be used to study the absorption rates and kinetics of labelled substances in the mucosal epithelium <jats:italic>in vivo<\/jats:italic>. The method was applied to the study of K transport by the mucosa of the descending colon of normal, Na\u2010depleted and adrenalectomized rats.<\/jats:p><jats:p>2. The K influx rate was linearly related to luminal [K] over the range 5\u201380 m\n<jats:sc>M<\/jats:sc>. NaCN in the lumen produced a fall of electrical potential difference (p.d.) and of K secretion rate but did not reduce K influx rate. The findings were consistent with passive K influx.<\/jats:p><jats:p>3. The mucosal <jats:sup>42<\/jats:sup>K content reached a steady value after 60\u201390 min of exposure to <jats:sup>42<\/jats:sup>K in the lumen. The value was similar in normal and adrenalectomized rats but was greater in Na\u2010depleted rats.<\/jats:p><jats:p>4. After replacement of luminal solution by a non\u2010radioactive solution the fall of mucosal <jats:sup>42<\/jats:sup>K content could be described, in the majority, by a curve having two exponential components with half\u2010times of 8\u201310 and 65\u2013106 min. Approximately half of the <jats:sup>42<\/jats:sup>K outflow passed to the lumen. The rate constants were similar in all groups of rats.<\/jats:p><jats:p>5. The results analysed on the basis of representing the mucosal K as in two compartments, indicated that the observed absorption rate could not be accounted for by transport through these compartments alone and that most of the <jats:sup>42<\/jats:sup>K crossed the mucosa by a fast pathway not detectable by the miniature GM counter. Most of the mucosal K was relatively inaccessible from the lumen.<\/jats:p><jats:p>6. Na depletion raised the transmucosal p.d., increased the K secretion rate and appeared to increase K permeability of the mucosa but the kinetics were unaltered. Accumulation of <jats:sup>42<\/jats:sup>K in the mucosa was greater, suggesting that the permeability of the luminal face had increased. Adrenalectomy produced only one change, namely a reduction of K secretion rate.<\/jats:p>","DOI":"10.1113\/jphysiol.1969.sp008988","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T12:04:10Z","timestamp":1418990650000},"page":"647-665","source":"Crossref","is-referenced-by-count":12,"title":["Use of a miniature GM counter and a whole body counter in the study of potassium transport by the colon of normal, sodium\u2010depleted and adrenalectomized rats <i>in vivo<\/i>"],"prefix":"10.1113","volume":"205","author":[{"given":"C. F.","family":"Barnaby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Edmonds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1969,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1969.sp008988","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1969.sp008988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T08:47:58Z","timestamp":1699433278000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1969.sp008988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,12]]}},"alternative-id":["10.1113\/jphysiol.1969.sp008988"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1969.sp008988","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,12]]}}}