{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:34:22Z","timestamp":1758396862858},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1970,2,1]],"date-time":"1970-02-01T00:00:00Z","timestamp":2678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,2]]},"abstract":"<jats:p>1. In chick embryo hearts, 3\u2010day\u2010old and not yet innervated, repetitive direct stimulation causes a transitory inhibition of the spontaneous rhythm.<\/jats:p><jats:p>2. The degree of post\u2010stimulation inhibition depends on the frequency and duration of the artificial stimulation and on the concentration of K and Ca ions in the extracellular solution.<\/jats:p><jats:p>3. After treatment with atropine (10<jats:sup>\u22125<\/jats:sup> g\/ml.) post\u2010stimulation inhibition is no longer observed. The spontaneous rhythm is accelerated by atropine. The findings therefore suggest that an ACh\u2010like substance is released from the non\u2010innervated embryonic heart during activity.<\/jats:p><jats:p>4. By use of the dorsal muscle of the leech for biological assay the liberation of an ACh\u2010like substance from the non\u2010innervated embryonic heart was confirmed.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009019","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:21:36Z","timestamp":1418988096000},"page":"383-395","source":"Crossref","is-referenced-by-count":24,"title":["Release of acetylcholine by chick embryo heart before innervation"],"prefix":"10.1113","volume":"206","author":[{"given":"E.","family":"Coraboeuf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Le Douarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Obrecht\u2010Coutris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1970,2]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:41:46Z","timestamp":1699461706000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,2]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009019"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009019","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,2]]}}}