{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:33:29Z","timestamp":1771623209821,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1970,3,1]],"date-time":"1970-03-01T00:00:00Z","timestamp":5097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,3]]},"abstract":"<jats:p>1. The post\u2010ganglionic nerve fibres to the vas deferens of the guinea\u2010pig and rat were interrupted <jats:italic>in vivo<\/jats:italic> by stripping one vas deferens of its serous coat; the other vas deferens was left intact as a control.<\/jats:p><jats:p>2. Four to eight days later the stripped vas deferens did not contract in response to electrical transmural stimulation <jats:italic>in vitro<\/jats:italic> at 0\u00b71 msec pulse duration. Pulses of 1\u00b70 msec duration produced small contractions which were not abolished by local anaesthetic or adrenergic neurone\u2010blocking drugs.<\/jats:p><jats:p>3. Log dose\u2014response curves to noradrenaline were, for stripped vasa deferentia, to the left of those for control vasa. The increase in sensitivity to noradrenaline at 8 days was about sixteenfold for rat vasa and about tenfold for guinea\u2010pig vasa. Tyramine did not contract stripped vasa from guinea\u2010pigs or rats.<\/jats:p><jats:p>4. The noradrenaline and adrenaline content of guinea\u2010pig and rat vasa was greatly reduced or abolished 8 days after the stripping operation.<\/jats:p><jats:p>5. Fluorescent nerve terminals were usually absent when transverse sections of stripped vasa were examined by fluorescence microscopy after treatment by the formaldehyde condensation method for demonstrating catecholamines.<\/jats:p><jats:p>6. It is concluded that post\u2010ganglionic sympathetic denervation is achieved by stripping the vas deferens <jats:italic>in vivo<\/jats:italic> of its serous coat and mesenteric attachments.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009035","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:21:21Z","timestamp":1418988081000},"page":"645-661","source":"Crossref","is-referenced-by-count":81,"title":["Sympathetic denervation of the smooth muscle of the vas deferens"],"prefix":"10.1113","volume":"206","author":[{"given":"A. T.","family":"Birmingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1970,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009035","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:41:10Z","timestamp":1699461670000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,3]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009035"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009035","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,3]]}}}