{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:28:26Z","timestamp":1771630106218,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1970,5,1]],"date-time":"1970-05-01T00:00:00Z","timestamp":10368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,5]]},"abstract":"<jats:p>1. Two atropine\u2010resistant response\u2010components of nervous origin have been detected in plexus\u2010containing preparations of the longitudinal muscle from the guinea\u2010pig ileum, by alternate field stimulation with equal numbers of pulses at 50 Hz (response A) and at 5 Hz (response B). With trains of ten or more pulses, response A is always larger than B; the ratio of A\/B (1\u00b72\u201321\u00b73) is subject to animal variation.<\/jats:p><jats:p>2. Both responses are abolished by tetrodotoxin and are absent from plexus\u2010free preparations.<\/jats:p><jats:p>3. Neither response is reduced by ganglion\u2010block with (+)\u2010tubocurarine, dimethyltubocurarine or hexamethonium, or by ganglion\u2010paralysing doses of nicotine; the contribution of excited preganglionic endings to these responses is therefore negligible.<\/jats:p><jats:p>4. Neither response is due to a release of histamine, 5\u2010hydroxytryptamine (5\u2010HT) or prostaglandins, since both A and B persist in the presence of mepyramine, methysergide and the prostaglandin\u2010antagonist SC\u201019220 (1\u2010acetyl\u20102(8\u2010chloro\u201010,11\u2010dihydrodibenz [b,f] [1,4]oxazepine\u201010\u2010carbonyl) hydrazine).<\/jats:p><jats:p>5. The two response\u2010components are affected differentially by a number of drugs.<\/jats:p><jats:p>6. Histamine, 0\u00b71 \u03bcg\/ml., reduces response A to the level of B; this selective inhibition of the histamine\u2010sensitive component in A is specifically antagonized by nicotine, 1\u20102\u00b75 \u00d7 10<jats:sup>\u22125<\/jats:sup> g\/ml.<\/jats:p><jats:p>7. 5\u2010HT, 0\u00b71 \u03bcg\/ml., and strychnine, 20\u201340 \u03bcg\/ml., also reduce response A to the level of B, but these selective inhibitions are not antagonized by nicotine.<\/jats:p><jats:p>8. Diphenhydramine, 10 \u03bcg\/ml., produces equality of the two responses by depressing A and potentiating B.<\/jats:p><jats:p>9. The inhibitory effects of the foregoing drugs are not due to catecholamine release, since they persist after \u03b1 + \u03b2 adrenoceptor blockade with phentolamine and pronethalol, and after previous reserpinization of the guinea\u2010pigs.<\/jats:p><jats:p>10. In atropinized plexus\u2010containing preparations of the longitudinal muscle from the guinea\u2010pig descending colon, the responses elicited at 50 Hz and at 5 Hz are virtually equal and both appear to be of Type B since they are not inhibited by histamine, 5\u2010HT or strychnine; diphenhydramine produces strong contractions.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009093","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:22:23Z","timestamp":1418988143000},"page":"761-782","source":"Crossref","is-referenced-by-count":37,"title":["Evidence for the release of two atropine\u2010resistant spasmogens from Auerbach's plexus"],"prefix":"10.1113","volume":"207","author":[{"given":"N.","family":"Ambache","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Verney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Aboo","family":"Zar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1970,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009093","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T20:40:34Z","timestamp":1699476034000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,5]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009093"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009093","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,5]]}}}