{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:09:24Z","timestamp":1790460564764,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1970,5,1]],"date-time":"1970-05-01T00:00:00Z","timestamp":10368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,5]]},"abstract":"<jats:p>1. Activity in forty\u2010two single chemoreceptor afferent fibres from the carotid body in thirty\u2010nine cats was measured when the carotid body was naturally and artificially perfused. In nine of these cats, carotid body venous flow was also measured.<\/jats:p><jats:p>2. When pressure within the carotid sinus segment was suddenly raised or lowered, chemoreceptor activity changed in the opposite direction within the first 5\u201010 sec by an amount which was significantly greater than the variation of activity in the control period. Thereafter activity stabilized at a level which was not different from control.<\/jats:p><jats:p>3. Whether the carotid body was naturally or artificially perfused, carotid body chemoreceptor activity, following this initial transient change, was unaffected in eight out of twelve fibres by alterations in carotid sinus pressure within the range 60\u2013160 mm Hg and carotid body venous flow 10\u201360 \u03bcl.\/min, blood gas tensions and pH being maintained constant. In the four remaining fibres, chemoreceptor activity increased slightly but significantly as pressure was lowered in this range. Chemoreceptor activity increased in all fibres tested when pressure was lowered below 50\u201360 mm Hg.<\/jats:p><jats:p>4. Chemoreceptor response curves to changes in <jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub> (30\u2013450 mm Hg), <jats:italic>P<\/jats:italic><jats:sub>a,CO2<\/jats:sub> (27\u201362 mm Hg) or [H<jats:sup>+<\/jats:sup>]<jats:sub>a<\/jats:sub> (3\u20137 \u00d7 10<jats:sup>\u22125<\/jats:sup>  m\u2010equiv\/l.) were not significantly different whether the carotid body was perfused (<jats:italic>a<\/jats:italic>) naturally at the prevalent systemic pressure, (<jats:italic>b<\/jats:italic>) artificially at the same pressure, or (<jats:italic>c<\/jats:italic>) artificially at one higher pressure, 130 or 140 mm Hg.<\/jats:p><jats:p>5. These results indicate that the carotid body chemoreceptors are relatively unaffected by sustained changes in arterial pressure or in total carotid body flow within the physiological range.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009108","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:24:36Z","timestamp":1418988276000},"page":"99-120","source":"Crossref","is-referenced-by-count":88,"title":["The relation between carotid body chemoreceptor discharge, carotid sinus pressure and carotid body venous flow"],"prefix":"10.1113","volume":"208","author":[{"given":"T. J.","family":"Biscoe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. W.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Purves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1970,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T15:40:30Z","timestamp":1699458030000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,5]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009108"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009108","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,5]]}}}