{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:10:17Z","timestamp":1791245417311,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1970,5,1]],"date-time":"1970-05-01T00:00:00Z","timestamp":10368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,5]]},"abstract":"<jats:p>1. The responses of single afferent fibres of carotid body chemoreceptors to independent changes in arterial O<jats:sub>2<\/jats:sub> and CO<jats:sub>2<\/jats:sub> tensions and pH were studied in the cat <jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p>2. The response curve obtained relating chemoreceptor activity to changes in arterial <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub> was similar to an hyperbola; the frequency of nerve impulses at first decreased rapidly as the <jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub> was raised and then more slowly. The arterial <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub> at which the slow decrease was reached varied among the different fibres; the mean level was 190 mm Hg (\n<jats:sc>S.D.<\/jats:sc> \u00b1 40 mm Hg).<\/jats:p><jats:p>3. Single chemoreceptor afferent fibres continued to discharge even when the arterial <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub> was more than 600 mm Hg.<\/jats:p><jats:p>4. The discharges of single chemoreceptor afferent fibres increased both with increasing <jats:italic>P<\/jats:italic><jats:sub>a,CO2<\/jats:sub> at constant pH and <jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub>, and with increasing arterial H<jats:sup>+<\/jats:sup> at constant <jats:italic>P<\/jats:italic><jats:sub>a,CO2<\/jats:sub> and <jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub>.<\/jats:p><jats:p>5. It is concluded that single carotid body chemoreceptor afferent fibres of the cat can be activated <jats:italic>in vivo<\/jats:italic> by an increase in either arterial H<jats:sup>+<\/jats:sup> or arterial <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> as well as by a decrease in arterial <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub>.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009109","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:24:36Z","timestamp":1418988276000},"page":"121-131","source":"Crossref","is-referenced-by-count":131,"title":["The frequency of nerve impulses in single carotid body chemoreceptor afferent fibres recorded <i>in vivo<\/i> with intact circulation"],"prefix":"10.1113","volume":"208","author":[{"given":"T. J.","family":"Biscoe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Purves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1970,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T15:40:38Z","timestamp":1699458038000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,5]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009109"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009109","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,5]]}}}