{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:25:38Z","timestamp":1789730738361,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1970,8,1]],"date-time":"1970-08-01T00:00:00Z","timestamp":18316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,8]]},"abstract":"<jats:p>1. Carotid body blood flow (c.b.f.) and carotid arterial\u2014carotid body venous oxygen (A\u2014V O<jats:sub>2<\/jats:sub>) difference were measured and carotid body oxygen consumption calculated in twenty\u2010six cats anaesthetized with pentobarbitone sodium, paralysed with gallamine triethiodide and ventilated mechanically.<\/jats:p><jats:p>2. With the sinus nerves intact and with blood gas tensions and carotid sinus pressure within physiological limits, section of either the pre\u2010 or post\u2010ganglionic cervical sympathetic nerve on the same side caused an average rise in c.b.f. of 9\u00b72 \u03bcl.\/min, in A\u2014V O<jats:sub>2<\/jats:sub> difference of 0\u00b709 ml.\/100 ml. and in carotid body oxygen consumption of 0\u00b7075 \u03bcl.\/min.<\/jats:p><jats:p>3. When the pre\u2010 or post\u2010ganglionic cervical sympathetic nerves were stimulated, c.b.f. and A\u2014V O<jats:sub>2<\/jats:sub> difference fell. The fall in c.b.f. was enhanced at high <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub>; the fall in A\u2014V O<jats:sub>2<\/jats:sub> difference and in calculated oxygen consumption was enhanced at low mean arterial pressure (\n<jats:sc>M.A.P.<\/jats:sc>) or <jats:italic>P<\/jats:italic><jats:sub>a, O2<\/jats:sub>.<\/jats:p><jats:p>4. Following sympathectomy, a reduction of \n<jats:sc>M.A.P.<\/jats:sc> at constant <jats:italic>P<\/jats:italic><jats:sub>a, O2<\/jats:sub> and <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub> caused a fall in c.b.f. and a commensurate rise in A\u2014V O<jats:sub>2<\/jats:sub> difference so that carotid body oxygen consumption remained approximately constant.<\/jats:p><jats:p>5. When <jats:italic>P<\/jats:italic><jats:sub>a, O2<\/jats:sub> was altered over the range 35 to &gt; 400 mm Hg, or <jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>, CO<jats:sub>2<\/jats:sub> over the range 27\u201370 mm Hg at constant \n<jats:sc>M.A.P.<\/jats:sc>, c.b.f. changed by amounts which were similar to those observed when the sympathetic nerves were intact and A\u2014V O<jats:sub>2<\/jats:sub> difference changed in the opposite direction so that carotid body oxygen consumption similarly remained constant.<\/jats:p><jats:p>6. Comparison of these results with those observed when the sympathetic nerves were intact indicates that the sympathetic nerves exert a vasoconstrictor effect upon carotid body blood vessels over a wide range of blood gas tensions and arterial pressure and that they also tend to diminish the rate of carotid body oxygen consumption. The mechanisms which may be involved in this regulation are discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009172","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:25:57Z","timestamp":1418988357000},"page":"417-431","source":"Crossref","is-referenced-by-count":40,"title":["The role of the cervical sympathetic nerve in the regulation of oxygen consumption of the carotid body of the cat"],"prefix":"10.1113","volume":"209","author":[{"given":"M. J.","family":"Purves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1970,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:29:57Z","timestamp":1699446597000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,8]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009172"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009172","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,8]]}}}