{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:03:45Z","timestamp":1778274225989,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1970,10,1]],"date-time":"1970-10-01T00:00:00Z","timestamp":23587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,10]]},"abstract":"<jats:p>1. Observations were made on the excretion of calcium and magnesium by the sheep's kidney following manipulation of the acid\u2014base status.<\/jats:p><jats:p>2. Intravascular administration of a synthetic solution resembling saliva abolished the naturally occurring acidosis in sheep during feeding, and it also prevented the normal onset of post\u2010prandial hypercalciuria and hypermagnesiuria.<\/jats:p><jats:p>3. Non\u2010respiratory acidosis (induced by infusion of hydrochloric acid) and respiratory acidosis arising from inhalation of 6% (v\/v) CO<jats:sub>2<\/jats:sub> in air both caused an acute increase in calcium excretion.<\/jats:p><jats:p>4. Measurement of filtered loads showed that feeding exerted an effect on the functional characteristics of the sheep's kidney. The renal clearances of calcium and magnesium increased, whereas sodium clearance decreased.<\/jats:p><jats:p>5. Experimental conditions were arranged so that variations in acid\u2014base status could be imposed at a time when the filtered load of calcium was declining.<\/jats:p><jats:p>6. With hydrochloric acid\u2010acidosis the renal excretion of calcium increased, despite a steady fall in the filtered load. With sodium bicarbonate alkalosis, the filtered load and the renal excretion of calcium decreased in unison.<\/jats:p><jats:p>7. These variations in calcium excretion were not accompanied by corresponding changes in the excretion of sodium.<\/jats:p><jats:p>8. It is concluded that the renal tubules in the sheep are sensitive to acid\u2014base status and that they respond to a lowering of the blood pH by decreasing the tubular reabsorption of filtered calcium.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009226","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:33:35Z","timestamp":1418988815000},"page":"549-564","source":"Crossref","is-referenced-by-count":49,"title":["Acidosis and hypercalciuria: renal mechanisms affecting calcium, magnesium and sodium excretion in the sheep"],"prefix":"10.1113","volume":"210","author":[{"given":"B. D.","family":"Stacy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. W.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1970,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009226","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:21:35Z","timestamp":1699435295000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,10]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,10]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009226"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009226","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,10]]}}}