{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:14:06Z","timestamp":1788999246731,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1970,11,1]],"date-time":"1970-11-01T00:00:00Z","timestamp":26265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,11]]},"abstract":"<jats:p>1. In anaesthetized open\u2010chest cats and dogs, blood flow and gas tensions were measured in a circuit inserted into a pulmonary vein while ventilating the lobe which it drained with low O<jats:sub>2<\/jats:sub> and high CO<jats:sub>2<\/jats:sub> mixtures.<\/jats:p><jats:p>2. Both hypoxic and hypercapnic mixtures caused a reduction in blood flow from the lobe.<\/jats:p><jats:p>3. Stimulus\u2014response curves relating blood flow to pulmonary venous <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub> and <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> were obtained. Those for hypoxia were usually asymptotic in shape; the curves became steep below 100 torr and flow sometimes fell to zero. The mean reduction in blood flow for every 20 torr fall in <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub> was 15\u00b77% in cats and 11\u00b78% in dogs. Those for hypercapnia were steep at first but levelled out at high <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> values; the maximum reduction in flow was 40\u201360% as vasoconstriction was only observed over a limited <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> range.<\/jats:p><jats:p>4. Hypoventilation of the lobe led to a reduction in blood flow. This was mainly attributable to hypoxia though other factors such as hypercapnia may sometimes have contributed.<\/jats:p><jats:p>5. Total occlusion of the bronchus of an O<jats:sub>2<\/jats:sub>\u2010filled lobe caused blood flow to fall in two phases. The first phase could be attributed to a rise in <jats:italic>P<\/jats:italic>CO<jats:sub>2<\/jats:sub> and the second to a fall in <jats:italic>P<\/jats:italic>O<jats:sub>2<\/jats:sub>.<\/jats:p><jats:p>6. The results confirm the hypothesis that hypoxia is an important factor regulating local blood flow in relation to local ventilation.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009271","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:29:45Z","timestamp":1418988585000},"page":"139-155","source":"Crossref","is-referenced-by-count":110,"title":["Stimulus\u2014response curves for the pulmonary vascular bed to hypoxia and hypercapnia"],"prefix":"10.1113","volume":"211","author":[{"given":"Gwenda R.","family":"Barer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1970,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009271","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T11:01:36Z","timestamp":1699441296000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,11]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009271"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009271","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,11]]}}}