{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:28:44Z","timestamp":1771622924862,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1971,5,1]],"date-time":"1971-05-01T00:00:00Z","timestamp":41904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,5]]},"abstract":"<jats:p>1. Ba<jats:sup>2+<\/jats:sup>, applied by micro\u2010iontophoresis, excites most cortical neurones that are excitable by ACh; other neurones tend to be depressed.<\/jats:p><jats:p>2. The discharges evoked by Ba<jats:sup>2+<\/jats:sup> resemble those evoked by ACh, but they have an even slower time course and are characterized by firing in high frequency bursts.<\/jats:p><jats:p>3. The excitatory action of Ba<jats:sup>2+<\/jats:sup>, unlike that of ACh, is not abolished by muscarine antagonists; but it can be prevented with dinitrophenol.<\/jats:p><jats:p>4. The depolarizing effect of Ba<jats:sup>2+<\/jats:sup> is associated with a rise in membrane resistance and it has a reversal level 24 mV more negative than the resting potential.<\/jats:p><jats:p>5. These observations suggest that, as in other tissues, Ba<jats:sup>2+<\/jats:sup> reduced the K<jats:sup>+<\/jats:sup> conductance by a direct action on the cell membrane. Some diminution in Na<jats:sup>+<\/jats:sup> inactivation is indicated by the repetitive firing at high frequency.<\/jats:p><jats:p>6. TEA has a predominantly depressant effect on all neurones tested. Like Ba<jats:sup>2+<\/jats:sup>, it often increases greatly the duration of spikes, but there is no regular change in resting membrane resistance and no tendency to repetitive firing. TEA probably reduces only the delayed K<jats:sup>+<\/jats:sup> current.<\/jats:p><jats:p>7. Even in large doses neither Ba<jats:sup>2+<\/jats:sup> nor TEA interferes with the conductance increase that generates the typical prolonged IPSPs recorded in cortical neurones.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009466","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:12:02Z","timestamp":1418987522000},"page":"223-245","source":"Crossref","is-referenced-by-count":67,"title":["Effects of Ba<sup>2+<\/sup> and tetraethylammonium on cortical neurones"],"prefix":"10.1113","volume":"215","author":[{"given":"K.","family":"Krnjevi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pumain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T18:25:24Z","timestamp":1699467924000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,5]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009466"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009466","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,5]]}}}