{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:50:46Z","timestamp":1699512646377},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1971,6,1]],"date-time":"1971-06-01T00:00:00Z","timestamp":44582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,6]]},"abstract":"<jats:p>1. Arterial blood samples were obtained from anaesthetized dogs in which either a respiratory alkalaemia, a respiratory acidaemia or a non\u2010respiratory acidaemia was produced and from animals in which no deliberate changes in acid\u2014base balance were produced. The samples were analysed for pH, carbon dioxide tension and concentration, oxygen tension and concentration and haematocrit. From these determinations the plasma carbon dioxide concentration, the plasma bicarbonate ion concentration and pK\u2032 were calculated.<\/jats:p><jats:p>2. The value of pK\u2032 lay within the range 5\u00b786\u20136\u00b727. The temperatures of the animals studied were between 36\u00b775 and 39\u00b725\u00b0 C but there was no significant relationship between pK\u2032 and temperature.<\/jats:p><jats:p>3. The values of pK\u2032 increased with an alkalaemia and decreased with an acidaemia.<\/jats:p><jats:p>4. In addition to the variation of pK\u2032 with pH there was a considerable residual scatter of pK\u2032 values at any one pH value.<\/jats:p><jats:p>5. It was concluded that in these experimental conditions the use of the Henderson\u2014Hasselbalch equation in a form not dealing with activities was unacceptable and could lead to much larger errors than has hitherto been thought.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009481","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:11:26Z","timestamp":1418987486000},"page":"491-507","source":"Crossref","is-referenced-by-count":4,"title":["The imprecision arising from the application of the Henderson\u2014Hasselbalch relationship to the blood of anaesthetized dogs"],"prefix":"10.1113","volume":"215","author":[{"given":"R. J.","family":"Linden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009481","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T18:26:40Z","timestamp":1699468000000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,6]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009481"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009481","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,6]]}}}