{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:49:26Z","timestamp":1758127766779},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1971,10,1]],"date-time":"1971-10-01T00:00:00Z","timestamp":55123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,10]]},"abstract":"<jats:p>1. The effect of prostaglandin E<jats:sub>1<\/jats:sub> (PGE<jats:sub>1<\/jats:sub>) on gastric secretion was studied in dogs equipped with gastric fundic pouches, either innervated (Pavlov) or denervated (Heidenhain).<\/jats:p><jats:p>2. PGE<jats:sub>1<\/jats:sub> inhibited gastric secretion (volume, acid concentration, acid output, pepsin output) when given either by constant intravenous infusion or by single intravenous injection. The degree of inhibition was dose dependent.<\/jats:p><jats:p>3. The antisecretory effect of PGE<jats:sub>1<\/jats:sub> was demonstrated against gastric stimulants which operate through different mechanisms. Thus, PGE<jats:sub>1<\/jats:sub> counteracted the secretogogue effect of:<\/jats:p><jats:p>(<jats:italic>a<\/jats:italic>) histamine dihydrochloride; the ED<jats:sub>50<\/jats:sub> was 0\u00b75\u20131\u00b70 \u03bcg\/kg. min for a submaximal dose, and 1\u00b70\u20131\u00b75 \u03bcg\/kg. min for a maximal dose;<\/jats:p><jats:p>(<jats:italic>b<\/jats:italic>) pentagastrin; the ED<jats:sub>50<\/jats:sub> was around 0\u00b725 \u03bcg\/kg. min;<\/jats:p><jats:p>(<jats:italic>c<\/jats:italic>) food; the ED<jats:sub>50<\/jats:sub> was 0\u00b75 to 0\u00b775 \u03bcg\/kg. min;<\/jats:p><jats:p>(<jats:italic>d<\/jats:italic>) 2\u2010deoxyglucose; the ED<jats:sub>50<\/jats:sub> was less than 0\u00b71 \u03bcg\/kg. min.<\/jats:p><jats:p>4. Although in some experiments, nausea and vomiting were observed during administration of PGE<jats:sub>1<\/jats:sub>, the antisecretory property of the substance is not related to a vomiting reflex, since<\/jats:p><jats:p>(<jats:italic>a<\/jats:italic>) an antiemetic, such as atropine, prevented vomiting without interfering with the effect of PGE<jats:sub>1<\/jats:sub>, and<\/jats:p><jats:p>(<jats:italic>b<\/jats:italic>) profuse vomiting elicited by apomorphine did not reduce gastric secretion stimulated by either histamine or pentagastrin.<\/jats:p><jats:p>5. The mechanism by which PGE<jats:sub>1<\/jats:sub> inhibits gastric secretion is unknown. Studies by others have shown that the compound reduces gastric mucosal blood flow, inhibits acid formation from gastric mucosa when applied <jats:italic>in vitro<\/jats:italic> and may change the rate of formation of gastric cyclic AMP. It is likely that PGE<jats:sub>1<\/jats:sub> interferes with biochemical processes, within parietal and chief cells, which lead to elaboration of gastric juice.<\/jats:p><jats:p>6. Unlike most gastric inhibitors, PGE<jats:sub>1<\/jats:sub> appears to act as a protective shield against most, if not all, gastric stimulants. Since prostaglandins of the E series are naturally occurring substances and are normally present in the stomach, they may play a role in the regulation of gastric secretion.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009623","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:14:48Z","timestamp":1418987688000},"page":"369-383","source":"Crossref","is-referenced-by-count":44,"title":["Inhibition by prostaglandin E<sub>1<\/sub> of gastric secretion in the dog"],"prefix":"10.1113","volume":"218","author":[{"given":"James E.","family":"Nezamis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Stowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:46:10Z","timestamp":1699451170000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,10]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009623"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009623","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,10]]}}}