{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:43:19Z","timestamp":1771645399570,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1971,10,1]],"date-time":"1971-10-01T00:00:00Z","timestamp":55123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,10]]},"abstract":"<jats:p>1. Angiotensin II\u2010like activity was estimated from the contraction of the rat ascending colon superfused with arterial blood in an extracorporeal circuit. The colon was calibrated by infusion of synthetic angiotensin II amide (Hypertensin, CIBA Ltd).<\/jats:p><jats:p>2. Resting levels of angiotensin II\u2010like activity were obtained by comparison of the length of a rat colon preparation superfused alternately with blood from an intact and from a nephrectomized rabbit.<\/jats:p><jats:p>3. The resting levels of angiotensin II\u2010like activity reached a maximum value of about 1\u00b76 ng\/ml. at 10\u201314 days of age, and thereafter declined to the adult value of 0\u00b723 ng\/ml. Rabbits of less than 100 g body weight had resting levels in the same range as adults.<\/jats:p><jats:p>4. Removal of 25% of the calculated blood volume induced five times greater increments in arterial angiotensin II\u2010like activity in immature than in adult rabbits (1\u00b768 \u00b1 0\u00b726 \n<jats:sc>S.E.<\/jats:sc> of mean ng\/ml. compared with 0\u00b734 \u00b1 0\u00b708 \n<jats:sc>S.E.<\/jats:sc> of mean ng\/ml.).<\/jats:p><jats:p>5. No evidence was obtained that the high levels of angiotensin II\u2010like activity encountered in immature rabbits were attributable to a slower rate of inactivation of angiotensin by tissues.<\/jats:p><jats:p>6. The pronounced activity of the renin\u2010angiotensin system demonstrated by these experiments in immature rabbits especially during haemorrhage is consistent with the suggestion that this system is of particular importance in cardiovascular control in early life.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009624","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:14:48Z","timestamp":1418987688000},"page":"385-403","source":"Crossref","is-referenced-by-count":21,"title":["Angiotensin II\u2010like activity in circulating arterial blood in immature and adult rabbits"],"prefix":"10.1113","volume":"218","author":[{"given":"Fiona Broughton","family":"Pipkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan C.","family":"Mott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. R. C.","family":"Roberton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:46:11Z","timestamp":1699451171000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,10]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009624"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009624","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,10]]}}}