{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:21:37Z","timestamp":1771626097757,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1971,12,1]],"date-time":"1971-12-01T00:00:00Z","timestamp":60393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,12]]},"abstract":"<jats:p>1. The taenia of the guinea\u2010pig caecum has been used as a model to study the re\u2010establishment of autonomic innervation following transplantation into the anterior eye chamber. The ultrastructure, the histochemical localization of noradrenaline and acetylcholinesterase and the pharmacology of transmission to the taenia have been examined 1 day to 16 weeks following transplantation. Both ganglion\u2010free strips of the taenia and caecal wall segments including the underlying Auerbach's plexus were used.<\/jats:p><jats:p>2. Caecal wall preparations: nerve fibres from intramural ganglion cells retracted during the first 2 days following transplantation, but reappeared in the muscle soon afterwards. Adrenergic nerves from the iris formed terminals about ganglion cells at about 2\u20104 weeks. Both cholinergic excitatory and non\u2010adrenergic (\u2018purinergic\u2019) inhibitory transmission to the muscle was re\u2010established by 2\u20104 days following transplantation.<\/jats:p><jats:p>3. Taenia strip preparations: both adrenergic and cholinergic nerve fibres were demonstrated histochemically in muscle bundles by 2\u20104 weeks. Non\u2010adrenergic inhibitory and cholinergic transmission was not re\u2010established until 2\u20104 weeks following transplantation. There was an abnormally dense re\u2010innervation of the muscle by adrenergic nerve fibres by about 8 weeks which is compared with the innervation of aganglionic bowel in Hirschsprung's disease.<\/jats:p><jats:p>4. The origin of non\u2010adrenergic inhibitory responses in the transplanted taenia is discussed and the results considered in relation to the re\u2010innervation of transplants of the vas deferens and of intestine during early development.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009654","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:18:48Z","timestamp":1418987928000},"page":"139-154","source":"Crossref","is-referenced-by-count":25,"title":["Changes in the physiology and fine structure of the taenia of the guinea\u2010pig caecum following transplantation into the anterior eye chamber"],"prefix":"10.1113","volume":"219","author":[{"given":"G.","family":"Burnstock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Gannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Malmfors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009654","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:53:53Z","timestamp":1699448033000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,12]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009654"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009654","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,12]]}}}