{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:07:51Z","timestamp":1791306471632,"version":"4.3.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1971,12,1]],"date-time":"1971-12-01T00:00:00Z","timestamp":60393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,12]]},"abstract":"<jats:p>1. Intracellular recordings were obtained from ganglion cells in the guinea\u2010pig inferior mesenteric ganglion (IMG) with a segment of the distal colon attached to the lumbar colonic nerves.<\/jats:p><jats:p>2. Continuous electrical activity consisting of excitatory synaptic potentials and action potentials was recorded from ganglion cells in all regions of the IMG.<\/jats:p><jats:p>3. The \u2018spontaneous\u2019 synaptic potentials were indistinguishable from those elicited by submaximal stimulation of any of the nerve trunks connected to the IMG.<\/jats:p><jats:p>4. The excitatory activity was irreversibly abolished when the lumbar colonic nerves were cut and reversibly abolished when tetrodotoxin (5 \u00d7 10<jats:sup>\u22127<\/jats:sup> g\/ml.) was added to the colon side of a two\u2010compartment organ bath.<\/jats:p><jats:p>5. Addition of dihydro\u2010\u03b2\u2010erythroidine (5 \u00d7 10<jats:sup>\u22126<\/jats:sup> g\/ml.) to the ganglion side of the bath abolished the synaptic activity of colonic origin and the synaptic responses to stimulation of any of the nerve trunks connected to the IMG.<\/jats:p><jats:p>6. Addition of dihydro\u2010\u03b2\u2010erythroidine (1 \u00d7 10<jats:sup>\u22125<\/jats:sup> g\/ml.) to the colon side of the bath markedly depressed the synaptic input of colonic origin but had no effect on synaptic responses produced by preganglionic nerve stimulation.<\/jats:p><jats:p>7. Distension of the colonic segment and the application of 5\u2010HT (1 \u00d7 10<jats:sup>\u22125<\/jats:sup> g\/ml.) to the mucosal surface of the colon increased the frequency of synaptic input.<\/jats:p><jats:p>8. The synaptic input from the colon was transiently blocked following repetitive stimulation of any of the nerve trunks connected to the IMG. The discharge of miniature synaptic potentials was unaffected.<\/jats:p><jats:p>9. Addition of noradrenaline (1 \u00d7 10<jats:sup>\u22127<\/jats:sup> to 1 \u00d7 10<jats:sup>\u22126<\/jats:sup> g\/ml.) to the colon side of the bath reduced, and in some cases completely abolished, the synaptic input to the IMG. Phentolamine (1 \u00d7 10<jats:sup>\u22126<\/jats:sup> g\/ml.), when added to the colon side of the bath, blocked the effect of noradrenaline and the transient inhibition following repetitive nerve stimulation.<\/jats:p><jats:p>10. Addition of noradrenaline (1 \u00d7 10<jats:sup>\u22124<\/jats:sup> g\/ml.) to the ganglion side of the bath reduced but never abolished the amplitude of the synaptic potentials of colonic origin.<\/jats:p><jats:p>11. It was concluded that in the guinea\u2010pig, the IMG is involved in a peripheral reflex whose afferent limit of this reflex consists of the axons of cholinergic neurones within the wall of the colon. Many of these neurones are driven either directly or indirectly by cholinergic synapses. The efferent noradrenergic neurones of the IMG function as a group of inhibitory neurones which depress the activity of the excitatory neurones of the colon which are driving them.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009671","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:17:36Z","timestamp":1418987856000},"page":"443-461","source":"Crossref","is-referenced-by-count":139,"title":["Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea\u2010pig"],"prefix":"10.1113","volume":"219","author":[{"given":"P. J.","family":"Crowcroft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie E.","family":"Holman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Szurszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1971,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009671","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:24:37Z","timestamp":1699449877000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,12]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,12]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009671"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009671","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,12]]}}}