{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T12:01:48Z","timestamp":1757592108367},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1972,5,1]],"date-time":"1972-05-01T00:00:00Z","timestamp":73526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>1. Although it is well established that exogenous noradrenaline injected into the diencephalon causes the satiated rat to eat, it is not known whether eating may be induced by release of endogenous diencephalic noradrenaline. In the present experiment 6\u2010hydroxydopamine was injected into the diencephalon of the rat to release catecholamines and produce degeneration of catecholamine\u2010containing neurones.<\/jats:p><jats:p>2. Injection into the preoptic area of 0\u00b701\u201316\u00b70 \u03bcg of 6\u2010hydroxydopamine caused satiated rats to eat.<\/jats:p><jats:p>3. All doses of 6\u2010hydroxydopamine above 0\u00b701 \u03bcg produced long\u2010lasting partial depletion of noradrenaline and dopamine in the region of the brain composed of septum, preoptic area and hypothalamus.<\/jats:p><jats:p>4. Repeated injections of 8 \u03bcg 6\u2010hydroxydopamine at intervals of several days caused progressively less eating.<\/jats:p><jats:p>5. Eating in response to 6\u2010hydroxydopamine was inhibited by pre\u2010treatment with desmethylimipramine, or by pre\u2010treatment with the adrenergic blocking agents phentolamine or MJ\u20101999.<\/jats:p><jats:p>6. Water intake after 6\u2010hydroxydopamine was reduced by pre\u2010treatment with desmethylimipramine or MJ\u20101999 but was enhanced after pre\u2010treatment with phentolamine.<\/jats:p><jats:p>7. It is concluded that release of diencephalic catecholamines by injection of 6\u2010hydroxydopamine causes eating in rats and that the catecholamine responsible for eliciting eating is noradrenaline.<\/jats:p>","DOI":"10.1113\/jphysiol.1972.sp009832","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:39:01Z","timestamp":1418985541000},"page":"35-47","source":"Crossref","is-referenced-by-count":32,"title":["Eating caused by 6\u2010hydroxydopamine\u2010induced release of noradrenaline in the diencephalon of the rat"],"prefix":"10.1113","volume":"223","author":[{"given":"K. D.","family":"Evetts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"Fitzsimons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulette E.","family":"Setler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1972,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1972.sp009832","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1972.sp009832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T10:22:19Z","timestamp":1699438939000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1972.sp009832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,5]]}},"alternative-id":["10.1113\/jphysiol.1972.sp009832"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1972.sp009832","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,5]]}}}