{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:45:11Z","timestamp":1758818711228},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1973,3,1]],"date-time":"1973-03-01T00:00:00Z","timestamp":99792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1973,3]]},"abstract":"<jats:p>1. Extracts of human stomach homogenized in Krebs solution had more PGE<jats:sub>2<\/jats:sub>\u2010like activity than tissue homogenized in acid\/ethanol or in the presence of indomethacin, indicating that the tissue can synthesize PGE<jats:sub>2<\/jats:sub>.<\/jats:p><jats:p>2. The distribution and synthesis of PGE<jats:sub>2<\/jats:sub>\u2010like substance in human stomach was determined by extracting frozen sections cut parallel to the mucosal surface. Peak levels usually occurred at a depth of 0\u2013600 \u03bcm in the mucosa.<\/jats:p><jats:p>3. Small amounts of a PGE<jats:sub>2<\/jats:sub>\u2010like substance were present in basal gastric juice, and its concentration was usually even lower in secretion stimulated by pentagastrin or histamine.<\/jats:p><jats:p>4. Submaximal acid secretion produced by I.V. infusion of pentagastrin generally fell slightly when indomethacin was administered rectally to inhibit PG synthesis.<\/jats:p><jats:p>5. These experiments, together with the findings that orally administered PGE compounds do not inhibit human gastric acid secretion, seem to argue against a possible inhibitory role for PGE<jats:sub>2<\/jats:sub> in gastric acid secretion in man.<\/jats:p><jats:p>6. If this is so, it would follow that gastric bleeding caused by aspirin\u2010like drugs is not due to increased acid secretion. A hypothesis is presented that tissue damage following vasoconstriction and ischaemia, due to inhibition of PG synthesis in blood vessels, contributes to the bleeding.<\/jats:p>","DOI":"10.1113\/jphysiol.1973.sp010142","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:21:02Z","timestamp":1418984462000},"page":"349-360","source":"Crossref","is-referenced-by-count":111,"title":["Prostaglandin E<sub>2<\/sub> and gastric acid secretion in man"],"prefix":"10.1113","volume":"229","author":[{"given":"A.","family":"Bennett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. F.","family":"Stamford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. G.","family":"Unger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1973,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1973.sp010142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1973.sp010142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T18:40:44Z","timestamp":1699468844000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1973.sp010142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1973,3]]}},"alternative-id":["10.1113\/jphysiol.1973.sp010142"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1973.sp010142","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,3]]}}}