{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:26:15Z","timestamp":1758925575899},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1973,6,1]],"date-time":"1973-06-01T00:00:00Z","timestamp":107740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1973,6]]},"abstract":"<jats:p>1. The possible role of active transport of Na in generating the transplacental potential difference (p.d.) was studied in the guinea\u2010pig placenta perfused <jats:italic>in situ<\/jats:italic> by testing the effects of strophanthin or KCN added to the perfusate or of Na\u2010free perfusion fluid.<\/jats:p><jats:p>2. The p.d. across the perfused placenta was about \u221220 mV, and was relatively steady during perfusion.<\/jats:p><jats:p>3. Strophanthin (10<jats:sup>\u22125<\/jats:sup> \n<jats:sc>M<\/jats:sc>) slightly increased the p.d. In a concentration of 2 \u00d7 10<jats:sup>\u22126<\/jats:sup> \n<jats:sc>M<\/jats:sc> strophanthin was without significant effect.<\/jats:p><jats:p>4. KCN (10<jats:sup>\u22123<\/jats:sup> \n<jats:sc>M<\/jats:sc>) decreased the p.d. When KCN was removed after a 30 min treatment the p.d. increased significantly exceeding the initial level. KCN (10<jats:sup>\u22124<\/jats:sup> \n<jats:sc>M<\/jats:sc>) slightly increased the p.d.<\/jats:p><jats:p>5. Perfusion with Na\u2010free fluid decreased the p.d. to a steady level of about 50\u201360% of the control values.<\/jats:p><jats:p>6. Perfusion with Na\u2010free fluid containing KCN (10<jats:sup>\u22123<\/jats:sup> \n<jats:sc>M<\/jats:sc>) for 30 min decreased the p.d. However, the effect did not seem different from the effect of KCN (10<jats:sup>\u22123<\/jats:sup> \n<jats:sc>M<\/jats:sc>) or Na\u2010free fluid alone. When KCN was removed the p.d. significantly increased in spite of continued perfusion with Na\u2010free fluid.<\/jats:p><jats:p>7. Excepting the effect of KCN (10<jats:sup>\u22124<\/jats:sup> \n<jats:sc>M<\/jats:sc>), which could not be explained, the observations were found to be consistent with active transport of Na from foetal to maternal side of the placenta as a source of the p.d. The Na transport could account for about 40\u201350% of the p.d.<\/jats:p>","DOI":"10.1113\/jphysiol.1973.sp010240","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:24:04Z","timestamp":1418984644000},"page":"403-415","source":"Crossref","is-referenced-by-count":7,"title":["Effects of potassium cyanide, strophanthin or sodium\u2010free perfusion fluid on the electrical potential difference across the guinea\u2010pig placenta perfused <i>in situ<\/i>"],"prefix":"10.1113","volume":"231","author":[{"given":"J.","family":"\u0160tulc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"\u0160vihovec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1973,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1973.sp010240","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1973.sp010240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:22:13Z","timestamp":1699446133000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1973.sp010240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1973,6]]}},"alternative-id":["10.1113\/jphysiol.1973.sp010240"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1973.sp010240","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,6]]}}}