{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:33:07Z","timestamp":1762075987678},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1974,1,1]],"date-time":"1974-01-01T00:00:00Z","timestamp":126230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:p>1. Injection of 5,6\u2010dihydroxytryptamine (5,6\u2010DHT, 50 \u03bcg) into a lateral cerebral ventricle of male rats lowered the 5\u2010hydroxytryptamine (5\u2010HT) content of the lumbar cord to 12\u00b78% and reduced the analgesic effect of low doses of morphine (0\u00b764\u20101\u00b763 mg\/kg), tested by exerting pressure on the foot; after doses of morphine of 1\u00b733\u20101\u00b763 mg\/kg, the analgesic response was reduced or abolished in 33% of the rats, and after 0\u00b764 mg\/kg, 58% of the animals failed to respond normally.<\/jats:p><jats:p>2. Two days after an \n<jats:sc>I.P.<\/jats:sc> injection of <jats:italic>p<\/jats:italic>\u2010chlorophenylalanine (<jats:italic>p<\/jats:italic>CPA, 320 mg\/kg), the loss of analgesic potency of morphine was more pronounced than after intraventricular 5,6\u2010HDT. The 5\u2010HT content was lowered to about 8% in the lumbar cord, and to 20% or less in pons and medulla.<\/jats:p><jats:p>3. The experiments show that interference with the descending tryptaminergic axons innervating the cord is by itself sufficient to reduce analgesia due to morphine, but they do not exclude the possibility that other tryptaminergic neurones take part in the effect of <jats:italic>p<\/jats:italic>CPA. The contribution to the analgesic effect of morphine made by the interaction of tryptaminergic axons with the interneurones \u2018gating\u2019 the afferent impulses in the posterior columns is discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1974.sp010448","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:17:20Z","timestamp":1418984240000},"page":"483-498","source":"Crossref","is-referenced-by-count":182,"title":["The effect of lowering the 5\u2010hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine"],"prefix":"10.1113","volume":"236","author":[{"given":"Marthe","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1974,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1974.sp010448","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1974.sp010448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T14:45:31Z","timestamp":1699454731000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1974.sp010448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1113\/jphysiol.1974.sp010448"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1974.sp010448","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}