{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:36:04Z","timestamp":1771644964593,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1974,7,1]],"date-time":"1974-07-01T00:00:00Z","timestamp":141868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1974,7]]},"abstract":"<jats:p>1. We have recorded afferent activity from \u2018single fibres\u2019 dissected from the superior laryngeal nerve of anaesthetized cats.<\/jats:p><jats:p>2. Units which responded to gentle mechanical stimulation of the larynx epithelium were chosen for study.<\/jats:p><jats:p>3. Receptors with myelinated fibres were grouped according to their spontaneous activity. Group 1 fibres had little or no spontaneous activity: group 2 fibres had constant and continuous spontaneous activity.<\/jats:p><jats:p>4. Group 1 fibres had a wide range of adaptation rates. Their conduction velocities lay between 3\u00b70 and 30 m\/sec. The receptors were generally stimulated by ammonia and distilled water and often by CS riot control agent, 5 and 10% CO<jats:sub>2<\/jats:sub>, 200 ppm SO<jats:sub>2<\/jats:sub>, and cigarette smoke. Histamine, phenyl diguanide, graphite dust, 100 ppm SO<jats:sub>2<\/jats:sub> and saline drops did not generally excite the fibres.<\/jats:p><jats:p>5. Group 2 fibres were slowly adapting. Their conduction velocities ranged between 8\u00b70 and 26\u00b75 m\/sec. Ammonia usually, and distilled water sometimes, excited these fibres while 5 and 10% CO<jats:sub>2<\/jats:sub> mixtures inhibited them. A minority of group 2 fibres were pH sensitive, inhibited by acids and stimulated by alkaline buffers. Cigarette smoke had complex actions, either excitation, inhibition or, at different times, both. Histamine, P.d.g., CS, SO<jats:sub>2<\/jats:sub>, saline drops and dust had no action on these fibres.<\/jats:p><jats:p>6. Recordings were made from one unmyelinated fibre (conduction velocity 1\u00b79 m\/sec) which responded to stroking of the epithelium with a thread and to histamine, P.d.g. and ammonia vapour applied to the epithelium.<\/jats:p><jats:p>7. We consider the site, method of excitation and reflex actions of the different receptors described.<\/jats:p>","DOI":"10.1113\/jphysiol.1974.sp010605","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:03:20Z","timestamp":1418983400000},"page":"153-175","source":"Crossref","is-referenced-by-count":163,"title":["The response of laryngeal afferent fibres to mechanical and chemical stimuli"],"prefix":"10.1113","volume":"240","author":[{"given":"H. A.","family":"Boushey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Widdicombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C. M.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1974,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1974.sp010605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1974.sp010605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T02:22:25Z","timestamp":1699150945000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1974.sp010605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,7]]}},"alternative-id":["10.1113\/jphysiol.1974.sp010605"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1974.sp010605","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,7]]}}}