{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:50:46Z","timestamp":1757544646153},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1974,7,1]],"date-time":"1974-07-01T00:00:00Z","timestamp":141868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1974,7]]},"abstract":"<jats:p>1. Cholera enterotoxin was used to evaluate a possible role of endogenous cyclic AMP in production of hyperthermia. Injection of purified toxin (0\u00b710\u20101\u00b70 \u03bcg in 0\u00b710 ml.) into the lateral cerebral ventricle of unanaesthetized cats caused dose\u2010related hyperthermic responses. Heating the toxin for 40 min at 90\u00b0 C abolished its hyperthermic activity.<\/jats:p><jats:p>2. Intraventricular administration of dibutyryl cyclic AMP (250\u20101000 \u03bcg) also caused hyperthermia which, however, was preceded by transient periods of hypothermia and\/or excitation in about half of the tests.<\/jats:p><jats:p>3. Paracetamol, indomethacin and sodium salicylate inhibited hyperthermic responses to cholera enterotoxin. Paracetamol and indomethacin also inhibited hyperthermia induced by dibutyryl cyclic AMP (sodium salicylate was not tested).<\/jats:p><jats:p>4. It is likely that the hyperthermic effect of cholera enterotoxin in the cat is mediated via endogenous cyclic AMP and that the antipyretics inhibit this effect by an action subsequent to the increase in cyclic AMP.<\/jats:p><jats:p>5. It is unlikely that prostaglandin\u2010induced hyperthermia in the cat is mediated via cyclic AMP since these antipyretics do not inhibit this response to prostaglandin E<jats:sub>1<\/jats:sub>.<\/jats:p>","DOI":"10.1113\/jphysiol.1974.sp010619","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:01:06Z","timestamp":1418983266000},"page":"493-504","source":"Crossref","is-referenced-by-count":32,"title":["The hyperthermic effect of intracerebroventricular cholera enterotoxin in the unanaesthetized cat"],"prefix":"10.1113","volume":"240","author":[{"given":"Wesley G.","family":"Clark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Rick","family":"Cumby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Henry E.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1974,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1974.sp010619","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1974.sp010619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T02:25:28Z","timestamp":1699151128000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1974.sp010619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,7]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,7]]}},"alternative-id":["10.1113\/jphysiol.1974.sp010619"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1974.sp010619","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,7]]}}}