{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:32:51Z","timestamp":1771623171225,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1974,12,1]],"date-time":"1974-12-01T00:00:00Z","timestamp":155088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1974,12]]},"abstract":"<jats:p>1. Molluscan neurones have been found to show six different types of response (three excitatory and three inhibitory) to the iontophoretic application of 5\u2010hydroxytryptamine (5\u2010HT). The pharmacological properties of the receptors and the ionic mechanisms associated with these responses have been analysed.<\/jats:p><jats:p>2. Four of the responses to 5\u2010HT (named <jats:italic>A, A\u2032, B<\/jats:italic> and <jats:italic>C<\/jats:italic>) are consequent upon an <jats:italic>increase<\/jats:italic> in membrane conductance whereas the other two (named \u03b1 and \u03b2) are caused by a <jats:italic>decrease<\/jats:italic> in membrane conductance.<\/jats:p><jats:p>3. The <jats:italic>A<\/jats:italic>\u2010response to 5\u2010HT consists of a \u2018fast\u2019 depolarization due to an increase mainly in Na<jats:sup>+<\/jats:sup>\u2010conductance; the <jats:italic>A\u2032<\/jats:italic>\u2010response is a \u2018slow\u2019 depolarization also associated with a Na<jats:sup>+<\/jats:sup>\u2010conductance increase. Receptors mediating the <jats:italic>A<\/jats:italic>\u2010 and <jats:italic>A\u2032<\/jats:italic>\u2010depolarizations have different pharmacological properties and may exist side by side on the same neurone.<\/jats:p><jats:p>4. Both the <jats:italic>B<\/jats:italic>\u2010 and <jats:italic>C<\/jats:italic>\u2010responses are inhibitory. The <jats:italic>B<\/jats:italic>\u2010response is a \u2018slow\u2019 hyperpolarization due to an increase in K<jats:sup>+<\/jats:sup>\u2010conductance, the <jats:italic>C<\/jats:italic>\u2010response is a fast hyperpolarization associated with an increase in Cl<jats:sup>\u2212<\/jats:sup>\u2010conductance.<\/jats:p><jats:p>5. The \u03b1\u2010response to 5\u2010HT is a depolarization which becomes reduced in amplitude with cell hyperpolarization and reverses at \u221275 mV; it is caused by a decrease in K<jats:sup>+<\/jats:sup>\u2010conductance. The \u03b2\u2010response is an hyperpolarization which increases in amplitude with cell hyperpolarization and reverses at \u221220\/\u221230 mV. It results from a decrease in conductance to both Na<jats:sup>+<\/jats:sup> and K<jats:sup>+<\/jats:sup> ions.<\/jats:p><jats:p>6. The receptors involved in the 5\u2010HT responses associated with a conductance increase may be recognized by the action of specific antagonists: 7\u2010methyltryptamine blocks only the <jats:italic>A<\/jats:italic>\u2010receptors, 5\u2010methoxygramine only the <jats:italic>B<\/jats:italic>\u2010receptors and neostigmine only the <jats:italic>C<\/jats:italic>\u2010receptors. Curare blocks the <jats:italic>A<\/jats:italic>\u2010 and <jats:italic>C<\/jats:italic>\u2010receptors and bufotenine, the <jats:italic>A<\/jats:italic>\u2010, <jats:italic>A\u2032<\/jats:italic>\u2010 and <jats:italic>B<\/jats:italic>\u2010receptors. No specific antagonists have yet been found for the 5\u2010HT responses caused by a conductance decrease.<\/jats:p><jats:p>7. The significance of the multiplicity of receptors is discussed. Their functional significance at synapses is analysed in the following paper.<\/jats:p>","DOI":"10.1113\/jphysiol.1974.sp010761","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:51:33Z","timestamp":1418982693000},"page":"427-456","source":"Crossref","is-referenced-by-count":203,"title":["Ionic mechanisms and receptor properties underlying the responses of molluscan neurones to 5\u2010hydroxytryptamine"],"prefix":"10.1113","volume":"243","author":[{"given":"H. M.","family":"Gerschenfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00e8le Paupardin","family":"Tritsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1974,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1974.sp010761","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1974.sp010761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T01:23:47Z","timestamp":1699233827000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1974.sp010761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,12]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,12]]}},"alternative-id":["10.1113\/jphysiol.1974.sp010761"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1974.sp010761","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,12]]}}}