{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:17:19Z","timestamp":1699831039218},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1975,7,1]],"date-time":"1975-07-01T00:00:00Z","timestamp":173404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1975,7]]},"abstract":"<jats:p>1. An electrophysiological study was made with the sucrose gap of the compound action potential of the non\u2010myelinated fibres of the garfish olfactory nerve at temperatures between 8 and 22 degrees C. The efflux of 42K with stimulation, and the post\u2010tetanic hyperpolarization following a period of repetitive stimulation, were also studied. 2. At 22 degrees C the compound action potential (at zero conduction distance) reached its peak in about 5 msec and lasted about 12 msec; the conduction velocity was 19.4 cm\/sec. The corresponding extrapolated values at 0 degrees C were: time to peak, 16 msec; duration, 37 msec; conduction velocity, 4.2 cm\/sec. 3. The rate constant for resting potassium efflux (kr) was 0.0108 min\u20101 at 22 degrees C and 0.00489 min\u20101 at 0 degrees C. 4. The extra fractional loss of potassium with stimulation (ks) was 2.02 x 10(\u22124) impulse\u20101 at 22 degrees C and 4.41 x 10(\u22124) impulse\u20101 at 0 degrees C. 5. Raising the external potassium concentration, or addition of ouabain (1 mM), raised the resting rate of efflux of potassium. 6. The post\u2010tetanic hyperpolarization, which reflects the electrogenic extrusion of sodium ions, indicated a rate constant for active sodium efflux at 22 degrees C of 0.47 min=1. 7. The rate constant was decreased by a 10 degrees C fall in temperature by a factor of 1.73. 8. Increasing the external potassium concentration increased the rate constant, apparently by potassium combining with some site with an equilibrium dissociation constant of 1.2 mMM. 9. The rate constant was decreased slightly in acidic solutions and increased slightly in alkaline solutions. 10. 14C\u2010labelled ouabain was found to bind to the garfish olfactory nerve with an equilibrium dissociation constant of about 0.5 muM. The maximum saturable binding capacity, 22.3 p\u2010mole\/mg dry, suggests that there are about 350 sodium pumping sites per square micron membrane.<\/jats:p>","DOI":"10.1113\/jphysiol.1975.sp011018","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:27:06Z","timestamp":1418981226000},"page":"327-348","source":"Crossref","is-referenced-by-count":16,"title":["The movement of potassium ions during electrical activity, and the kinetics of the recovery process, in the non\u2010myelinated fibres of the garfish olfactory nerve."],"prefix":"10.1113","volume":"249","author":[{"given":"J M","family":"Ritchie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1975,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1975.sp011018","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1975.sp011018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T04:12:52Z","timestamp":1699243972000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1975.sp011018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,7]]}},"alternative-id":["10.1113\/jphysiol.1975.sp011018"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1975.sp011018","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,7]]}}}