{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:36:00Z","timestamp":1757540160913},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1975,12,1]],"date-time":"1975-12-01T00:00:00Z","timestamp":186624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1975,12]]},"abstract":"<jats:p>1. It is well known that red blood cells suspended in isotonic NH4Cl solution swell because penetration of NH3 induces a transmembrane exchange between Cl\u2010o and OH\u2010i(or HCO3\u2010i). The rate of swelling thus depends on the speed of the transmembrane exchanges and on the amount of anions available for exchange. 2. It has been demonstrated in experiments carried out in a CO2\u2010free medium that OH\u2010ions are poorly permeating whereas the permeability for HCO3\u2010is very high. Thus the rate of swelling is largely dependent on the intracellular HCO3\u2010concentration. In this context the well\u2010known inhibitory effect of sulphonamides upon swelling can be interpreted, and always has been until now, as being due to the inhibitory action of the drug on the intracellular carbonic anhydrase. However, this inhibitory effect could also result from a direct action of the drug on the transmembrane exchange; it would explain why under conditions of total carbonic anhydrase inhibition we have shown that the inhibition of swelling is far from maximal. 3. A direct experimental evidence of such an effect of carbonic anhydrase inhibitors on the transmembrane exchange of Cl\u2010with HCO3\u2010 was obtained with benzolamide (Cl 11,366), Cl 13,580 and ethoxzolamide. Surprisingly enough, however, acetazolamide (Diamox) does not affect the transmembrane exchange process. 4. The inhibitory effect of sulphonamides on HCO3\u2010transport process is discussed in terms of an interaction of the drug with a transport system common to HCO3\u2010 and organic anions.<\/jats:p>","DOI":"10.1113\/jphysiol.1975.sp011195","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:30:09Z","timestamp":1418981409000},"page":"385-399","source":"Crossref","is-referenced-by-count":33,"title":["Transmembrane exchange of chloride with bicarbonate ion in mammalian red blood cells: evidence for a sulphonamide\u2010sensitive \"carrier\"."],"prefix":"10.1113","volume":"253","author":[{"given":"J L","family":"Cousin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Motais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1975,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1975.sp011195","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1975.sp011195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T04:04:05Z","timestamp":1699243445000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1975.sp011195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,12]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,12]]}},"alternative-id":["10.1113\/jphysiol.1975.sp011195"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1975.sp011195","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,12]]}}}