{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:27:24Z","timestamp":1771630044861,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1976,5,1]],"date-time":"1976-05-01T00:00:00Z","timestamp":199756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:p>1. The effects of histamine on gastric mucosal blood flow in the presence and absence of gastric acid secretion were studied in the rat. 2. Histamine, in doses greater than those required to stimulate maximal acid secretion, caused a small increase in mucosal blood flow per unit acid output. 3. When acid secretion was inhibited by methyl analogues of prostaglandin E2, histamine reduced arterial blood pressure and gave a dose dependent rise in mucosal blood flow. 4. When acid secretion was inhibited by the histamine H2\u2010receptor antagonists, burimamide and metiamide, histamine still increased mucosal blood flow. 5. The use of H1\u2010receptor antagonists to inhibit the histamine\u2010induced hyperaemia was made difficult by their vasodilator actions. 6. The selective histamine H2\u2010receptor agonist, 4\u2010methyl histamine, had no effect on arterial blood pressure in doses which stimulated acid secretion. The increase in mucosal blood flow which accompanied the stimulation of acid secretion was inhibited by the anti\u2010secretory prostaglandins and H2\u2010receptor antagonists. 7. The selective histamine H1\u2010receptor agonist, 2\u2010pyridyl ethylamine, had no effect on acid output but increased resting mucosal blood flow. 8. These results suggest that histamine H2\u2010receptors, primarily concerned with acid secretion, and H1\u2010receptors concerned with vasodilatation are both present in the rat gastric mucosa.<\/jats:p>","DOI":"10.1113\/jphysiol.1976.sp011375","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:02:27Z","timestamp":1418979747000},"page":"407-418","source":"Crossref","is-referenced-by-count":46,"title":["A study of the vascular and acid\u2010secretory responses of the rat gastric mucosa to histamine."],"prefix":"10.1113","volume":"257","author":[{"given":"I H","family":"Main","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Whittle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1976,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1976.sp011375","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1976.sp011375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:28:02Z","timestamp":1699270082000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1976.sp011375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,5]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,5]]}},"alternative-id":["10.1113\/jphysiol.1976.sp011375"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1976.sp011375","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,5]]}}}