{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:57:45Z","timestamp":1756994265067},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1976,6,1]],"date-time":"1976-06-01T00:00:00Z","timestamp":202435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1976,6]]},"abstract":"<jats:p>1. Pentobarbitone or phenobarbitone, in increasing concentrations up to 0\u20105 mM, progressively reduced the amplitude of miniature end\u2010plate potentials (min.e.p.p.s). Pentobarbitone was the more potent of the two barbiturates in this regard. 2. Both barbiturates produced a monotonic increase in mean quantum content of the end\u2010plate potential (e.p.p.) with increasing concentrations up to 0\u20105 mM. Pentobarbitone and phenobarbitone were equally potent in their action on evoked transmitter release. 3. The effect, if any, of increasing concentrations of barbiturates on the e.p.p. amplitude was depression. Therefore, over the range of concentrations examined the enhancement of transmitter release was quantitatively less than the reduction in responsiveness of the post\u2010synaptic membrane. 4. Because of the greater ratio of post\u2010synaptic to presynaptic actions, pentobarbitone was more potent than phenobarbitone in reducing synaptic efficacy (e.p.p. amplitude). 5. It is concluded that the presynaptic actions of pentobarbitone and phenobarbitone contribute significantly to barbiturate\u2010induced changes in synaptic efficacy at low levels of transmitter release in the frog neuromuscular junction.<\/jats:p>","DOI":"10.1113\/jphysiol.1976.sp011418","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:04:16Z","timestamp":1418979856000},"page":"257-268","source":"Crossref","is-referenced-by-count":21,"title":["A comparison of the presynaptic and post\u2010synaptic actions of pentobarbitone and phenobarbitone in the neuromuscular junction of the frog."],"prefix":"10.1113","volume":"258","author":[{"given":"W R","family":"Proctor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J N","family":"Weakly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1976,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1976.sp011418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1976.sp011418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:42:44Z","timestamp":1699231364000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1976.sp011418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,6]]}},"alternative-id":["10.1113\/jphysiol.1976.sp011418"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1976.sp011418","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,6]]}}}