{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:09:27Z","timestamp":1770437367321,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1976,8,1]],"date-time":"1976-08-01T00:00:00Z","timestamp":207705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1976,8]]},"abstract":"<jats:p>1. The argyrophil (enterochromaffin\u2010like) cells in the oxyntic gland area of the rat stomach contain histamine, which can be demonstrated fluorescence microscopically after exposure to gaseous OPT. After administration of L\u2010dopa (or L\u20105\u2010hydroxytryptophan), these cells produce and temporarily store dopamine (or 5\u2010hydroxytryptamine), demonstrable by its characteristic formaldehyde\u2010induced fluorescence. Ultrastructurally, the enterochromaffin\u2010like cells, which have the appearance of polypeptide hormone\u2010secreting cells, comprise two main cell types, the most predominant one having vesicular type granules (EGL cells), the second most predominant one having smaller, uniformly electron dense granules (A\u2010like cells). 2. Rats were subjected to the following surgical treatments: antrectomy; porta\u2010caval shunting; antrectomy+porta\u2010caval shunting; or sham\u2010operation. Three to eight weeks after surgery the histamine\u2010storing cells (enterochromaffin\u2010like cells) of the oxyntic mucosa were analysed by fluorescence histochemistry, light and (quantitative) electron microscopy, and fluorometric determination of amines. 3. After antrectomy, fluorescence histochemistry and silver staining revealed a reduced number of enterochromaffin\u2010like cells. The histamine content in the oxyntic mucosa was reduced by about 50%. As in unoperated injection of pentagastrin seemed to mobilize histamine. Feeding or injection of insulin failed to do so in antrectomized as opposed to control rats. Ultrastructurally, the cytoplasmic granules of both endocrine\u2010like cell types were less numerous than in the unoperated rats. The reduction in cell number and granularity was particularly conspicuous with regard to the EGL cells. 4. After porta\u2010caval shunting the number of enterochromaffin\u2010like cells increased markedly. Chemical determination revealed a twofold increase in the histamine concentration of the oxyntic mucosa. Feeding or injection of insulin or pentagastrin lowered the histamine concentration. As judged by electron microscopy, the proliferation of endocrine\u2010like cells induced by porta\u2010caval shunting was restricted to the ECL cell type. Besides occurring in greater number, these cells were larger than those in unoperated controls, and their cytoplasm was densely packed with granules that were increased in size. 5. Following antrectomy of the porta\u2010caval shunted rats the number of enterochromaffin\u2010like cells and the oxyntic histamine concentration was reduced. 6. The results support the idea that gastrin exerts trophic as well as excitatory effects on oxyntic endocrine\u2010like cells.<\/jats:p>","DOI":"10.1113\/jphysiol.1976.sp011495","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:04:32Z","timestamp":1418979872000},"page":"785-800","source":"Crossref","is-referenced-by-count":78,"title":["Effects of antrectomy or porta\u2010caval shunting on the histamine\u2010storing endocrine\u2010like cells in oxyntic mucosa of rat stomach. A fluorescence histochemical, electron microscopic and chemical study."],"prefix":"10.1113","volume":"259","author":[{"given":"R","family":"H\u00e4kanson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L I","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Liedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Oscarson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sundler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1976,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1976.sp011495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1976.sp011495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T17:50:36Z","timestamp":1699206636000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1976.sp011495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,8]]}},"alternative-id":["10.1113\/jphysiol.1976.sp011495"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1976.sp011495","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,8]]}}}