{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:17:32Z","timestamp":1761059852197},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1976,10,1]],"date-time":"1976-10-01T00:00:00Z","timestamp":212976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1976,10]]},"abstract":"<jats:p>1. A new method of labelling saxitoxin (STX) is described, based on transfer of tritium from tritiated water to the toxin. 2. The radiochemical purity of the labelled toxin has been directly determined, rather than being based on indirect biochemical means, as in previous experiments with Wilzbach\u2010labelled STX and TTX. 3. The specific activity of the labelled toxin, 66 d..m.f\u2010mole\u20101, corresponds with one tritium atom per molecule STX, an improvement of about 300\u2010fold over other means of labelling TTX and STX. 4. The binding of this toxin to rabbit, lobster and garfish olfactory nerve fibres has been re\u2010examined. 5. The density of sodium channels calculated on the basis of the binding of the toxin is about four to six\u2010times the values previously reported.<\/jats:p>","DOI":"10.1113\/jphysiol.1976.sp011569","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:07:56Z","timestamp":1418980076000},"page":"477-494","source":"Crossref","is-referenced-by-count":140,"title":["A new method for labelling saxitoxin and its binding to non\u2010myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves."],"prefix":"10.1113","volume":"261","author":[{"given":"J M","family":"Ritchie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Rogart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G R","family":"Strichartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1976,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1976.sp011569","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1976.sp011569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T05:13:08Z","timestamp":1699247588000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1976.sp011569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,10]]}},"alternative-id":["10.1113\/jphysiol.1976.sp011569"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1976.sp011569","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,10]]}}}